# US 8,540,970 B2 · Composition for treating xerostomia or dry mouth

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- Number: US 8,540,970 B2
- Document ID: US8540970B2
- Status: Granted
- Kind: B2
- Application number: 12/036,005
- Filed: 2008-02-22
- Published: 2008-10-02
- Granted: 2013-09-24
- Earliest claimed: 2007-02-22
- Assignees: Biocosmetics, S.L.
- Applicants: Debora Rodriguez-Vilaboa
- Inventors: Debora Rodriguez-Vilaboa
- Web page: https://patentgrep.com/patent/US8540970B2

## CPC

- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 8/046: {Aerosols; Foams}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/922: {of vegetable origin}
- A61K 31/7004: Monosaccharides having only carbon, hydrogen and oxygen atoms
- A61K 36/63: Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention provides a composition comprising olive oil, trimethylglycine and xylitol for treating xerostomia and disorders associated thereto, with very good results in increasing the unstimulated salivary flow, in alleviating the symptoms of xerostomia, including the pain associated to xerostomia, as well as improving the quality of life of affected persons. The composition of the invention has also been proved to protect dentin against demineralization in acid conditions.

## Claims

### Claim 1

A composition for treating xerostomia characterised in that it comprises 0.1-4% by weight of olive oil, 0.1-6% by weight of trimethylglycine and 1-50% by weight of xylitol.

### Claim 2 (depends on 1)

A composition according to claim 1, characterised in that it comprises 0.2-3% by weight of olive oil.

### Claim 3 (depends on 2)

A composition according to claim 2, characterised in that it comprises 2% by weight of olive oil.

### Claim 4 (depends on 1)

A composition according to claim 1, characterised in that it comprises 4% by weight of trimethylglycine.

### Claim 5 (depends on 1)

A composition according to claim 1, characterised in that it comprises 5-30% by weight of xylitol.

### Claim 6 (depends on 5)

A composition according to claim 5, characterised in that it comprises 10% by weight of xylitol.

### Claim 7 (depends on 1)

A composition according to claim 1, characterised in that it comprises 2% by weight of olive oil, 4% by weight of trimethylglycine and 10% by weight of xylitol.

### Claim 8 (depends on 1)

A composition according to claim 1, characterised in that it comprises 2% by weight of olive oil, 2% by weight of trimethylglycine and 1% by weight of xylitol.

### Claim 9 (depends on 1)

A composition according to claim 1, characterized in that it comprises one or more components selected from the group constituted by remineralising agents, viscosity-controlling agents, moisturising agents, preservatives, colorants, buffer agents, sweeteners, proteolytic enzymes, emulsifiers, abrasives, essential oils, cicatrizing agents, aromas, antioxidants, plant and animal gelatines, excipients, and a mixture thereof.

### Claim 10 (depends on 1)

A composition according to claim 1, comprising 1% by weight of olive oil.

### Claim 11 (depends on 1)

A composition according to claim 1, comprising 1% by weight of olive oil, 4% by weight of trimethylglycine, and 10% by weight of xylitol.

### Claim 12 (depends on 1)

A composition according to claim 1, characterised in that it is formulated as a toothpaste, mouthwash, salivary substitute, spray, gel, chewing gum, suckable capsules, suckable lozenges, palate sheets, tablets, sweets, impregnated oral swabs, impregnated oral gauzes, suckable single-dose presentations of frozen solution.