# US 8,540,968 B2 · Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof

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- Number: US 8,540,968 B2
- Document ID: US8540968B2
- Status: Granted
- Kind: B2
- Application number: 11/316,620
- Filed: 2005-12-20
- Published: 2007-01-25
- Granted: 2013-09-24
- Earliest claimed: 2004-03-02
- Assignees: Cellectar, Inc.
- Applicants: Jamey Weichert; Marc Longino; Anatoly Pinchuk
- Inventors: Jamey Weichert; Marc Longino; Anatoly Pinchuk
- Web page: https://patentgrep.com/patent/US8540968B2

## CPC

- A61K 51/0408: {Phospholipids (liposomes encapsulating the radioactive probe or having no radiolabelled phospholipids A61K51/1231)}
- A61K 49/0017: {Fluorescence in vivo}
- A61K 51/04: Organic compounds
- C07F 13/005: {Compounds without a metal-carbon linkage}
- G01N 33/5759: {involving compounds localised on the membrane of tumour or cancer cells}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting of Lung cancer, Adrenal cancer, Melanoma, Colon cancer, Colorectal cancer, Ovarian cancer, Prostate cancer, Liver cancer, Subcutaneous cancer, Squamous cell cancer, Intestinal cancer, Hepatocellular carcinoma, Retinoblastoma, Cervical cancer, Glioma, Breast cancer and Pancreatic cancer in subject using phospholipid ether analogs.

## Claims

### Claim 1

A method for detecting and locating a cancer in vivo, the method comprising the steps of:
administering 124I-labeled 18-(p-Iodophenyl)octadecyl phosphocholine to the human subject; and
determining whether an organ suspected of having the cancer in the subject retains a higher level of 124I-labeled 18-(p-Iodophenyl)octadecyl phosphocholine than surrounding region(s), wherein a higher retention region indicates detection and location of the cancer, wherein the detection is carried out by PET scanning.

### Claim 2 (depends on 1)

The method of claim 1, wherein the detection is carried out by a combination of PET scanning and CT or MRI scanning methods.

### Claim 3 (depends on 1)

The method of claim 1, wherein the cancer is selected from the group consisting of lung cancer, squamous cell carcinoma, melanoma, colorectal cancer, ovarian cancer, prostate cancer, glioma, breast cancer, carcinosarcoma, and pancreatic cancer.

### Claim 4 (depends on 1)

The method of claim 1, comprising administering between about 0.5 μCi and about 500 mCi of the 124I-labeled 18-(p-Iodophenyl)octadecyl phosphocholine to the human subject.

### Claim 5 (depends on 1)

The method of claim 1, comprising administering less than 0.3 μg/kg of body weight of the 124I-labeled 18-(p-Iodophenyl)octadecyl phosphocholine to the human subject.