Single wall nanotube constructs and uses therefor

A method of treating a pathophysiological state in a subject, comprising:

• administering a soluble single wall carbon nanotube (SWNT) construct functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereon, wherein the SWNT construct has a structure of SWNT-(DNA1,2-(cDNA1-peptide)m-(cDNA2-M*tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA))n)x, such that cDNA1 is linked to the peptide, cDNA2 is linked to DOTA and DNA1,2 is linked to the SWNT;
• and,
• wherein cDNA1 and cDNA2 independently are non-identical oligomers and DNA1,2 is an oligomer with a sequence complementary to cDNA1 and cDNA2;
• and,
• wherein said DNA1,2 is the sequence shown in SEQ ID NO:
• 1, said cDNA1 is the sequence shown in SEQ ID NO:
• 2, and said cDNA2 is the sequence shown in SEQ ID NO:
• 3;
• and,
• wherein said peptide is an antibody or a targeting cyclic RGD or an NGR peptide ligand, M* is a radionuclide, x is 1 to 300;
• and m and n are independently 1 to 300;
• and
• wherein, upon targeting cells associated with the pathophysiological state with said targeting moiety, said payload has a therapeutic effect against said cells or elicits a therapeutic effect from said cells thereby treating the pathophysiological state in the subject.