# US 8,540,955 B2 · Process for producing aluminum phosphate

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- Number: US 8,540,955 B2
- Document ID: US8540955B2
- Status: Granted
- Kind: B2
- Application number: 12/169,665
- Filed: 2008-07-09
- Published: 2009-01-15
- Granted: 2013-09-24
- Earliest claimed: 2007-07-10
- Assignees: Wyeth
- Applicants: Lakshmi Khandke; Joseph Perez
- Inventors: Lakshmi Khandke; Joseph Perez
- Web page: https://patentgrep.com/patent/US8540955B2

## CPC

- C01B 25/36: Aluminium phosphates
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 33/42: Phosphorus; Compounds thereof
- C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention provides improved methods for producing the aluminum adjuvant AlPO4. In one aspect, the present invention provides a method for producing aluminum phosphate which comprises the steps of mixing a solution of aluminum chloride and a solution of sodium phosphate tribasic to produce an aluminum phosphate precipitate, wherein the improvement comprises settling the aluminum phosphate precipitate at a temperature in the range of about 50° C. to about 70° C. In another aspect, the present invention is directed to methods for producing aluminum phosphate within a closed system.

## Claims

### Claim 1

A method for producing an aluminum phosphate vaccine adjuvant comprising:
mixing a solution of aluminum chloride and a solution of sodium phosphate tribasic to produce an aluminum phosphate suspension and a supernatant, wherein the solution of sodium phosphate tribasic is added to the solution of aluminum chloride until the pH is in the range of 5.0 to 5.4;
settling the aluminum phosphate suspension to produce an aluminum phosphate precipitate, wherein the settling step is performed for a period of about 2 days to about 5 days and at a temperature of about 60° C.;
removing the supernatant, wherein the steps of mixing, settling and removing are performed within a closed system;
sterilizing the aluminum phosphate precipitate, wherein the step of sterilizing comprises heating the aluminum phosphate precipitate to a temperature in excess of 110° C.; and
adjusting the pH of the aluminum phosphate precipitate to be in the range of 5.6 to 6.0, wherein after the step of adjusting the pH, the aluminum phosphate precipitate includes particles with a size distribution having a D [v, 0.5] in the range of 3.0 μm to 9.0 μm.

### Claim 2 (depends on 1)

The method of claim 1, wherein the solution of sodium phosphate tribasic is added to the solution of aluminum chloride until the pH of the resulting suspension of aluminum phosphate is in the range of 5.1 to 5.3.

### Claim 3 (depends on 1)

The method of claim 1, wherein the mixing step is performed at a temperature of about 25° C.

### Claim 4 (depends on 1)

The method of claim 1, wherein the pH of the aluminum phosphate precipitate is adjusted to be in the range of about 5.9 to about 6.0.

### Claim 5 (depends on 1)

The method of claim 1, wherein the concentration of aluminum phosphate in the aluminum phosphate suspension after the step of mixing is in the range of about 9.0 to about 16.5 mg/ml.

### Claim 6 (depends on 1)

The method of claim 1, wherein after the step of adjusting the pH, the aluminum phosphate precipitate includes particles with a size distribution having a D [v, 0.5] in the range of about 4.5 μm to about 6.5 μm.

### Claim 7 (depends on 1)

The method of claim 1, wherein after the step of adjusting the pH, the aluminum phosphate precipitate includes particles with a size distribution having a D [v, 0.1] of more than about 2.0 μm.

### Claim 8 (depends on 1)

The method of claim 1, wherein after the step of adjusting the pH, the aluminum phosphate precipitate includes particles with a size distribution having a D [v, 0.9] of less than about 20 μm.

### Claim 9 (depends on 1)

The method of claim 1, wherein after the step of adjusting the pH, the aluminum phosphate precipitate includes particles with a size distribution having a D [v, 0.9] of less than about 21 μm.

### Claim 10 (depends on 1)

The method of claim 1, wherein after the step of adjusting the pH, the aluminum phosphate precipitate includes particles with a size distribution having a D [v, 0.9] of less than about 22 μm.

### Claim 11 (depends on 1)

The method of claim 1, wherein after the step of adjusting the pH, the aluminum phosphate precipitate includes particles with a size distribution having a D [v, 0.9] of less than about 23 μm.

### Claim 12 (depends on 1)

The method of claim 1, wherein after the step of adjusting the pH, the aluminum phosphate precipitate includes particles with a size distribution having a D [v, 0.9] of less than about 24 μm.