# US 8,540,815 B2 · Preparation for magnesium ammonium phosphate cements > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,540,815 B2 - Document ID: US8540815B2 - Status: Granted - Kind: B2 - Application number: 12/918,591 - Filed: 2009-02-18 - Published: 2011-02-03 - Granted: 2013-09-24 - Earliest claimed: 2008-02-20 - Assignees: InnoTERE GmbH - Applicants: Uwe Gbureck - Inventors: Uwe Gbureck - Web page: https://patentgrep.com/patent/US8540815B2 ## CPC - C04B 28/34: containing cold phosphate binders - A61L 24/0042: {Materials resorbable by the body} - A61L 24/02: containing inorganic materials - B33Y 80/00: Products made by additive manufacturing - C04B 2111/00836: {for medical or dental applications} - C04B: LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE {(roofing granules E04D7/005)}; CERAMICS (devitrified glass-ceramics C03C10/00); REFRACTORIES; TREATMENT OF NATURAL STONE - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - B33Y: ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING ## Abstract The invention relates to a preparation for a magnesium ammonium phosphate cement. There is provided a preparation comprising (a) a magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y≦4, x>1, y>0, z=x+y−3 and z≧0; (b) an ammonium salt; and (c) water; wherein the ammonium salt and the water can be present partially or completely as an aqueous solution of the ammonium salt. ## Claims ### Claim 1 A composition for a magnesium ammonium phosphate cement comprising: (a) a magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y≦4, x>1, y>0, z=x+y−3 and z≧0; (b) an ammonium salt; and (c) water. ### Claim 2 (depends on 1) The composition according to claim 1 wherein the magnesium calcium phosphate has a Mg/P molar ratio in the range of 0.51, y>0, z=x+y−3 and z≧0 with ammonium salt and water or with an aqueous solution of the ammonium salt until a homogenous mixture is obtained; (b) applying the homogenous mixture to a target object; and (c) causing the homogenous mixture to harden, thereby obtaining set magnesium ammonium phosphate cement. ### Claim 18 (depends on 17) The process according to claim 17 wherein step (a) comprises mixing the magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y≦4, x>1, y>0, z=x+y−3 and z≧0 with the aqueous solution of the ammonium salt. ### Claim 19 (depends on 17) The process according to claim 17, wherein the magnesium ammonium phosphate cement is used for at least one of the group comprising bone replacement, bone filler, and bone adhesive. ### Claim 20 (depends on 17) The process according to claim 17, wherein the magnesium ammonium phosphate cement is used for a preformed implant. ### Claim 21 (depends on 17) The process according to claim 17 wherein the composition or the magnesium ammonium phosphate cement acts as a support for pharmaceutically active ingredients. ### Claim 22 (depends on 1) The composition according to claim 1 wherein the composition further comprises at least one selected from the group consisting of viscosity affecting and pore forming excipients. ### Claim 23 A composition for a magnesium ammonium phosphate cement comprising: (a) a magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y≦4, x>1, y>0, z=x+y−3 and z≧0, wherein the magnesium calcium phosphate is selected from the group consisting of sintered magnesium calcium phosphate, powdered magnesium calcium phosphate having a mean particle size in the range of 0.5 to 10 μm, Mg2.25Ca0.75(PO4)2, Mg2.5Ca0.5(PO4)2, and Mg2.75Ca0.25(PO4)2; (b) an ammonium salt, wherein the ammonium salt is selected from the group consisting of monoammonium salts of phosphoric acid, monoammonium salts of citric acid, monoammonium salts of tartaric acid, monoammonium salts of sulfuric acid, monoammonium salts of acetic acid, diammonium salts of phosphoric acid, diammonium salts of citric acid, diammonium salts of tartaric acid, diammonium salts of sulfuric acid, diammonium salts of acetic acid, and mixtures thereof, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, and a mixture of diammonium hydrogen phosphate and ammonium dihydrogen phosphate; (c) water; and, (d) at least one of the group comprising pharmaceutically active ingredients, viscosity affecting excipients, pore forming excipients, injectivity affecting excipients, cohesion affecting excipients, paste consistency affecting excipients, porosity affecting excipients, resorptivity affecting excipients, adhesion to the bone affecting excipients, stability in storage affecting excipients, compatibility with active ingredients affecting excipients, and release affecting excipients. ### Claim 24 (depends on 1) The composition according to claim 1 wherein the ammonium salt and the water is present as an aqueous solution of the ammonium salt. ### Claim 25 (depends on 23) The composition according to claim 23 wherein the ammonium salt and the water is present as an aqueous solution of the ammonium salt.