# US 8,540,766 B2 · Biofilm formation inhibitor and treatment device thereof

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- Number: US 8,540,766 B2
- Document ID: US8540766B2
- Status: Granted
- Kind: B2
- Application number: 11/719,819
- Filed: 2005-11-16
- Published: 2009-04-16
- Granted: 2013-09-24
- Earliest claimed: 2004-11-22
- Assignees: Kyushu University, National University Corporation
- Applicants: Takehisa Matsuda; Ryo Maeyama
- Inventors: Takehisa Matsuda; Ryo Maeyama
- Web page: https://patentgrep.com/patent/US8540766B2

## CPC

- A01N 25/10: Macromolecular compounds
- A01N 43/16: with oxygen as the ring hetero atom
- A01N 65/08: Magnoliopsida [dicotyledons]
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61P 31/04: Antibacterial agents
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A treatment device such as a biliary stent, capable of effectively and continuously inhibiting biofilm formation, and a biofilm formation inhibitor suitable for coating on the treatment device by killing all bacteria including E. coli and by suppressing the growth of these bacteria, are provided. A biofilm formation inhibitor having an effective amount of catechin for inhibiting biofilm formation and a carrier that is suitable for adhesion of said catechin to a treatment device to be placed in the living body, are provided.

## Claims

### Claim 1

A biofilm formation inhibitor comprising an effective amount of an isolated catechin for inhibiting biofilm formation by E. Coli and a hydrophilic biodegradable polymer that is suitable for adhesion of said catechin to a biliary stent to be placed in a living body and that is capable of sustained releasing of said isolated catechin and surface erosion.

### Claim 2 (depends on 1)

The biofilm formation inhibitor of claim 1, wherein said catechin is epigallocatechin gallate.

### Claim 3 (depends on 1)

The biofilm formation inhibitor of claim 1, wherein said catechin is contained in said carrier in an amount such that a sustained release of said catechin per day is at least 0.22 mg/cm2.

### Claim 4

A biliary stent to be placed in a living body, wherein an effective amount of an isolated catechin for inhibiting biofilm formation by E. Coli is coated on the surface thereon with a hydrophilic biodegradable polymer, and which allows sustained releasing of said catechin and surface erosion.

### Claim 5 (depends on 4)

The biliary stent of claim 4, wherein said biliary stent is a plastic stent of a non-self-expandable type.

### Claim 6 (depends on 4)

The biliary stent of claim 4, wherein said catechin is coated thereon as contained in a carrier in an amount such that a sustained release of said catechin per day is at least 0.22 mg/cm2.

### Claim 7 (depends on 1)

The biofilm formation inhibitor of claim 1, wherein said hydrophilic biodegradable polymer is selected from the group consisting of TMC/LL/PEG1k, TMC/PEG200, and TMC/TMP.

### Claim 8 (depends on 4)

The biliary stent of claim 4, wherein said hydrophilic biodegradable polymer selected from the group consisting of TMC/LL/PEG1k, TMC/PEG200, and TMC/TMP.

### Claim 9 (depends on 1)

The biofilm formation inhibitor of claim 1, wherein said isolated catechin is selected from the group consisting of catechin, epicatechin, gallo catechin, epigallocatechin, catechin gallate, epi-catechin gallate, gallocatechin gallate, and epigallocatechin gallate.

### Claim 10 (depends on 4)

The biliary stent of claim 4, wherein said isolated catechin is selected from the group consisting of catechin, epicatechin, gallo catechin, epigallocatechin, catechin gallate, epi-catechin gallate, gallocatechin gallate, and epigallocatechin gallate.