# US 8,540,722 B2 · Methods, materials and apparatus for treating bone and other tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,540,722 B2 - Document ID: US8540722B2 - Status: Granted - Kind: B2 - Application number: 12/485,098 - Filed: 2009-06-16 - Published: 2009-10-22 - Granted: 2013-09-24 - Earliest claimed: 2003-06-17 - Assignees: DePuy Synthes Products, Inc. - Applicants: Mordechay Beyar; Oren Globerman; Abraham Domb; Ronen Shavit; Hila Wachsler-Avrahami - Inventors: Mordechay Beyar; Oren Globerman; Abraham Domb; Ronen Shavit; Hila Wachsler-Avrahami - Web page: https://patentgrep.com/patent/US8540722B2 ## CPC - A61B 17/8852: {capable of being assembled or enlarged, or changing shape, inside the bone or disc} - A61B 17/7095: {the filler comprising unlinked macroscopic particles} - A61B 17/8805: {for introducing fluid filler into bone or extracting it (A61B17/7097, A61B17/8833 take precedence)} - A61B 17/8811: {characterised by the introducer tip, i.e. the part inserted into or onto the bone} - A61B 17/8816: {characterised by the conduit, e.g. tube, along which fluid flows into the body or by conduit connections} - A61B 17/8822: {characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum} - A61B 17/8833: {Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means} - A61L 24/06: obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} - A61L 27/16: obtained by reactions only involving carbon-to-carbon unsaturated bonds - B01F 27/1143: screw-shaped, e.g. worms - B01F 33/86: {Mixing heads comprising a driven stirrer} - B01F 35/123: {using scrapers for cleaning mixers} - B01F 35/531: {with baffles, plates or bars on the wall or the bottom} - B01F 35/754251: {reciprocating in the mixing receptacle} - A61B 17/8819: {characterised by the introducer proximal part, e.g. cannula handle, or by parts which are inserted inside each other, e.g. stylet and cannula (A61B17/8825 takes precedence)} - A61B 2017/00539: {hydraulically} - A61B 2017/00734: {battery operated} - A61L 2400/06: Flowable or injectable implant compositions - A61L 2430/38: for reconstruction of the spine, vertebrae or intervertebral discs - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - B01F: MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING (mixing paints B44D3/06) ## Abstract A method of treating a vertebra, comprising: (a) accessing an interior of a vertebra; and (b) introducing a sufficient amount of artificial biocompatible material which does not set to a hardened condition in storage, into said bone, with sufficient force to move apart fractured portions of said bone. ## Claims ### Claim 1 A method of treating a vertebra, comprising: (a) inserting a delivery device into an interior of a vertebra; (b) introducing bone cement through the delivery device and into the vertebra without an enclosure between the bone cement and the vertebra; and (c) manipulating the delivery device, as the bone cement flows through the delivery device, to change an introduction direction of the bone cement; wherein a sufficient amount of bone cement is delivered to the interior of the vertebra with sufficient force to move apart fractured portions of the vertebra. ### Claim 2 (depends on 1) A method according to claim 1, wherein the bone cement sets to a hardened condition after introduction into the body. ### Claim 3 (depends on 1) A method according to claim 1, wherein the bone cement does not set to a hardened condition in storage. ### Claim 4 (depends on 1) A method according to claim 1, wherein the bone cement is a viscous fluid. ### Claim 5 (depends on 4) A method according to claim 4, wherein the bone cement has a viscosity between 600 Pascal-second and 1,800 Pascal-second. ### Claim 6 (depends on 1) A method according to claim 1, wherein introducing comprises introducing at a pressure of at least 40 atmospheres. ### Claim 7 (depends on 1) A method according to claim 1, wherein introducing comprises introducing at a pressure of at least 100 atmospheres. ### Claim 8 (depends on 1) A method according to claim 1, wherein the delivery device has a diameter of less than 6 mm and a length of at least 70 mm. ### Claim 9 (depends on 1) A method according to claim 1, wherein the bone cement is introduced through an extrusion aperture formed in the delivery device and having a minimum dimension of less than 3 mm. ### Claim 10 (depends on 1) A method according to claim 1, wherein the bone cement is introduced through an extrusion aperture formed in the delivery device and having a minimum dimension of less than 1.5 mm. ### Claim 11 (depends on 1) A method according to claim 1, wherein introducing comprises introducing the bone cement through a plurality of extrusion apertures simultaneously, the plurality of extrusion apertures being formed in the delivery device. ### Claim 12 (depends on 1) A method according to claim 1, further comprising manipulating the delivery device to change an introduction position of the bone cement. ### Claim 13 (depends on 1) A method according to claim 1, wherein introducing comprises advancing the bone cement using a motor. ### Claim 14 (depends on 1) A method according to claim 1, wherein introducing comprises advancing the bone cement using a hydraulic source. ### Claim 15 (depends on 1) A method according to claim 1, wherein introducing comprises introducing the bone cement in discrete unit amounts. ### Claim 16 (depends on 15) A method according to claim 15, wherein at least some of the units have different mechanical properties from each other. ### Claim 17 (depends on 1) A method according to claim 1, wherein introducing comprises cutting the bone cement away from the delivery device. ### Claim 18 (depends on 1) A method according to claim 1, wherein introducing comprises not twisting the delivery device during said introducing. ### Claim 19 (depends on 1) A method according to claim 1, wherein introducing comprises shaping an extrusion form of the bone cement using an exit aperture formed in the delivery device. ### Claim 20 (depends on 1) A method according to claim 1, wherein introducing comprises introducing without a separate void forming act. ### Claim 21 (depends on 1) A method according to claim 1, wherein said introduced material is operative to support at least 30% of a weight of vertebra within a week after implantation. ### Claim 22 A method of treating bone, comprising: (a) inserting a delivery device into an interior of a bone; and (b) introducing bone cement into the bone through a plurality of extrusion apertures formed in the delivery device, without a separate void forming act and without an enclosure between the cement and the bone, and with sufficient force to move apart fractured portions of the bone. ### Claim 23 (depends on 22) A method according to claim 22, comprising leaving the bone cement in said bone to resist at least 30% of a normative force which urges said portions together. ### Claim 24 (depends on 22) A method according to claim 22, wherein said bone is a vertebra. ### Claim 25 (depends on 24) A method according to claim 24, wherein the bone cement does not set to a hardened condition in storage. ### Claim 26 (depends on 22) The method according to claim 22, wherein the delivery device comprises a cannula. ### Claim 27 (depends on 1) The method according to claim 1, further comprising inserting a cannula into a body, and inserting the delivery device through the cannula prior to introducing the bone cement. ### Claim 28 (depends on 1) The method according to claim 1, wherein manipulating the delivery device comprises rotating the delivery device as the bone cement flows into the vertebra. ### Claim 29 (depends on 1) The method according to claim 1, further comprising removing the delivery device from a first access hole formed in the vertebra and inserting the delivery device through a second access hole formed in the vertebra. ### Claim 30 (depends on 29) The method according to claim 29, further comprising introducing the bone cement while the delivery device is positioned in the second access hole. ### Claim 31 (depends on 1) The method according to claim 1, further comprising inflating a balloon to create a cavity in the vertebra prior to inserting the delivery device into the vertebra. ### Claim 32 (depends on 22) The method according to claim 22, further comprising manipulating the delivery device to change an introduction position of the bone cement. ### Claim 33 (depends on 32) The method according to claim 32, wherein manipulating comprises moving the delivery device axially to direct the bone cement to a desired location in the bone. ### Claim 34 (depends on 12) The method according to claim 12, wherein manipulating comprises moving the delivery device axially to direct the bone cement to a desired location in the vertebra. ### Claim 35 A method of treating a vertebra, comprising: (a) inserting a delivery device into an interior of a vertebra; and (b) introducing bone cement through the delivery device and into the vertebra without a separate void forming act and without an enclosure between the bone cement and the vertebra; wherein a sufficient amount of bone cement is delivered to the interior of the vertebra with sufficient force to move apart fractured portions of the vertebra. ### Claim 36 (depends on 35) The method according to claim 35, wherein manipulating the delivery device comprises rotating the delivery device as the bone cement flows into the vertebra. ### Claim 37 (depends on 35) The method according to claim 35, wherein manipulating comprises moving the delivery device axially to direct the bone cement to a desired location in the bone. ### Claim 38 (depends on 35) The method according to claim 35, wherein introducing comprises advancing the bone cement using a motor. ### Claim 39 (depends on 35) The method according to claim 35, wherein introducing comprises advancing the bone cement using a hydraulic source. ### Claim 40 (depends on 35) The method according to claim 35, wherein the bone cement is a viscous fluid. ### Claim 41 (depends on 35) The method according to claim 35, wherein the bone cement has a viscosity between 600 Pascal-second and 1,800 Pascal-second. ### Claim 42 (depends on 35) The method according to claim 35, wherein introducing comprises introducing at a pressure of at least 40 atmospheres. ### Claim 43 (depends on 35) The method according to claim 35, wherein introducing comprises introducing at a pressure of at least 100 atmospheres. ### Claim 44 (depends on 35) The method according to claim 35, wherein introducing comprises introducing the bone cement through at least one extrusion aperture formed in a sidewall of the delivery device.