# US 8,540,710 B2 · Methods and apparatuses for tissue treatment > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,540,710 B2 - Document ID: US8540710B2 - Status: Granted - Kind: B2 - Application number: 13/609,369 - Filed: 2012-09-11 - Published: 2013-01-03 - Granted: 2013-09-24 - Earliest claimed: 2000-07-25 - Assignees: AngioDynamics, Inc. - Applicants: Theodore C. Johnson; Daniel J. Balbierz; Robert M. Pearson - Inventors: Theodore C. Johnson; Daniel J. Balbierz; Robert M. Pearson - Web page: https://patentgrep.com/patent/US8540710B2 ## CPC - A61B 18/18: by applying electromagnetic radiation, e.g. microwaves - A61B 18/1477: {Needle-like probes} - A61B 2018/00011: {with fluids} - A61B 2018/00083: {low, i.e. electrically insulating} - A61B 2018/00196: {reciprocating lengthwise} - A61B 2018/00577: {Ablation} - A61B 2018/00642: {with feedback, i.e. closed loop control} - A61B 2018/00654: {with individual control of each of a plurality of energy emitting elements} - A61B 2018/00875: {Resistance or impedance} - A61B 2018/124: {switching the output to different electrodes, e.g. sequentially} - A61B 2018/1273: {including multiple generators in one device} - A61B 2018/128: {generating two or more frequencies} - A61B 2018/1497: {Electrodes covering only part of the probe circumference} - A61B 2218/002: Irrigation - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Disclosed in the present application are devices for localized delivery of energy and methods of using such devices, particularly for therapeutic treatment of biological tissues. The disclosed methods may involve positioning and deploying the energy delivery members in a target site, and delivering energy through the energy delivery members. The disclosed devices may also be used to create a tissue tract within a biological tissue and to ablate the tissue tract. ## Claims ### Claim 1 A method of ablating a tissue tract, comprising: providing an energy delivery member configured for insertion into a target tissue; inserting the delivery member into an insertion site; advancing the delivery member thereby forming a tissue tract, extending from the insertion site to the target tissue, substantially five of tumor cells; delivering energy sufficient to ablate substantially all tumor cells in the target tissue; withdrawing the delivery member along the formed tissue tract; and delivering energy to at least a portion of the formed tissue tract. ### Claim 2 (depends on 1) The method of claim 1, wherein the method further comprises delivering electrical energy in the form of electrical pulses sufficient to electroporate substantially all tumor cells along the formed tract while leaving tissue surrounding the tumor cells substantially unchanged. ### Claim 3 (depends on 1) The method of claim 1, wherein the method farther comprises delivering radiofrequency energy during the step of delivering energy sufficient to ablate substantially all tumor cells in the target tissue. ### Claim 4 (depends on 1) The method of claim 1, wherein the method further comprises delivering microwave energy during the step of delivering energy sufficient to ablate substantially all tumor cells in the target tissue. ### Claim 5 (depends on 1) The method of claim 1, wherein the method farther comprises delivering laser energy during the step of delivering energy sufficient to ablate substantially all tumor cells in the target tissue. ### Claim 6 (depends on 1) The method of claim 1, wherein the method further comprises selectively delivering varying amounts of energy to different portions of the tissue tract during the step of delivering, energy sufficient to ablate substantially all tumor cells in the target tissue. ### Claim 7 (depends on 1) The method of claim 1, wherein the method further comprises ablating substantially all tumor cells that are present along the tissue tract. ### Claim 8 (depends on 1) The method of claim 1, wherein the method further comprises delivering energy in the form of electrical energy in a monopolar mode during the step of delivering energy sufficient to ablate substantially all tumor cells in the target tissue. ### Claim 9 (depends on 1) The method of claim 1, wherein the method further comprises delivering energy in the form of electrical energy in a bipolar mode during the step of delivering energy sufficient to ablate substantially all tumor cells in the target tissue. ### Claim 10 (depends on 1) The method of claim 1, wherein the method farther comprises monitoring and altering the delivery of the energy to the tissue tract during the step of delivering energy to ensure that no living malignant tissue is re-seeded along the tract upon withdrawal of the energy delivery device. ### Claim 11 (depends on 1) The method of claim 1, wherein the method further comprises continuously withdrawing the energy delivery device along the tissue tract while delivering energy to at least a portion of the formed tissue tract. ### Claim 12 (depends on 1) The method of claim 1, wherein the method further comprises delivering a fluid to the tissue tract. ### Claim 13 (depends on 1) The method of claim 1, wherein the method further comprises removing aspirated tissue from the tissue tract. ### Claim 14 (depends on 3) The method of claim 3, wherein the method further comprises delivering radiofrequency energy during the step of delivering energy sufficient to ablate at least a portion of the formed tissue tract. ### Claim 15 (depends on 4) The method of claim 4, wherein the method further comprises delivering microwave energy during the step of delivering energy sufficient to ablate at least a portion of the formed tissue tract. ### Claim 16 (depends on 5) The method of claim 5, wherein the method further comprises delivering laser energy during the step of delivering energy sufficient to ablate at least a portion of the formed tissue tract. ### Claim 17 (depends on 1) The method of claim 1, wherein the step of delivering energy sufficient to ablate substantially all tumor cells in the target tissue further includes controlling the energy level with at least one logic resource. ### Claim 18 (depends on 17) The method of claim 17, wherein the logic resource controls the energy level based on measurement of impedance. ### Claim 19 (depends on 1) The method of claim 1, further comprising the step of monitoring the localized impedance. ### Claim 20 (depends on 1) The method of claim 1, further comprising using an ablation monitoring module to determine an ablation endpoint by monitoring an impedance of the target tissue. ### Claim 21 (depends on 20) The method of claim 20, wherein the ablation monitoring module determines the ablation endpoint by using impedance measurements made at multiple frequencies. ### Claim 22 (depends on 20) The method of claim 20, wherein the ablation monitoring module determines the ablation endpoint by comparing at least two impedance curves made at different frequencies. ### Claim 23 (depends on 1) The method of claim 1, wherein delivering energy to at least a portion of the thrilled tissue tract includes directing, to the tissue tract, an ablation energy which is higher than the ablation energy directed to the target tissue. ### Claim 24 (depends on 1) The method of claim 1, further comprising delivering cooling fluid to a lumen of the energy delivery member. ### Claim 25 (depends on 24) The method of claim 24, wherein the delivery of cooling fluid is controlled by a controller.