# US 8,540,617 B2 · Extracorporeal pumping methods > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,540,617 B2 - Document ID: US8540617B2 - Status: Granted - Kind: B2 - Application number: 13/468,972 - Filed: 2012-05-10 - Published: 2012-09-27 - Granted: 2013-09-24 - Earliest claimed: 2007-04-20 - Assignees: Medical Engineering Corporation - Applicants: Tani Tatum; Stephen Walker; Robert W Wilson - Inventors: Tani Tatum; Stephen Walker; Robert W Wilson - Web page: https://patentgrep.com/patent/US8540617B2 ## CPC - A61M 1/3666: {Cardiac or cardiopulmonary bypass, e.g. heart-lung machines} - A01N 1/143: for organ perfusion - A61M 1/3667: {with assisted venous return} - A61M 60/113: in other functional devices, e.g. dialysers or heart-lung machines - A61M 60/274: the inlet and outlet being the same, e.g. para-aortic counter-pulsation blood pumps - A61M 60/38: Blood oxygenation - A61M 60/427: the force acting on the blood contacting member being hydraulic or pneumatic - A61M 2205/505: Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches - A61M 2240/00: Specially adapted for neonatal use - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS ## Abstract An extracorporeal pumping method includes receiving an inlet fluid into a compressible-expandable bladder sealably mounted within a housing and moving an actuating member mounted within a fluid chamber of a hydraulic actuating sub-assembly. A pressure transmissive fluid is displaced from the fluid chamber into the housing. The method includes compressing a volume of the bladder in the housing using the transmissive fluid displaced into the housing, the compressed bladder ejecting the inlet fluid from the bladder to provide an outlet fluid under pulsatile pressure. The actuating member is moved within the fluid chamber and the displaced transmissive fluid is returned from the housing into the fluid chamber. The method includes expanding the compressed bladder in the housing and receiving additional inlet fluid into the bladder. The movement of the actuating member is controlled such that the outlet fluid exhibits a predetermined pulse rate, stroke volume, and upstroke rise time. ## Claims ### Claim 1 An extracorporeal pumping method comprising: receiving an inlet fluid into a compressible-expandable bladder sealably mounted within a housing; moving an actuating member mounted within a fluid chamber of a hydraulic actuating sub-assembly, the fluid chamber containing a pressure transmissive fluid, and displacing transmissive fluid from the fluid chamber into the housing; compressing a volume of the bladder in the housing the transmissive fluid displaced into the housing, the compressed bladder ejecting the inlet fluid from the bladder to provide an outlet fluid under pulsatile pressure; introducing the outlet fluid into a blood vessel and thereby pumping blood through the blood vessel under the pulsatile pressure; moving the actuating member within the fluid chamber and returning the displaced transmissive fluid from the housing into the fluid chamber; expanding the compressed bladder in the housing and receiving additional inlet fluid into the bladder; and controlling the movement of the actuating member such that the outlet fluid exhibits a predetermined pulse rate, stroke volume, and upstroke rise time. ### Claim 2 (depends on 1) The method of claim 1 wherein the movement of the actuating member is controlled using a programmable motion controller. ### Claim 3 (depends on 2) The method of claim 2 wherein the motion controller controls pulse rate, stroke volume, and upstroke rise time independently. ### Claim 4 (depends on 3) The method of claim 3 further comprising programming the predetermined pulse rate, stroke volume, or upstroke rise time into the motion controller using a programmable touch screen. ### Claim 5 (depends on 3) The method of claim 3 further comprising programming the predetermined pulse rate into the motion controller using an EKG trigger. ### Claim 6 (depends on 1) The method of claim 1 wherein the inlet fluid is received into the bladder through a first valve. ### Claim 7 (depends on 6) The method of claim 6 wherein the first valve is a tricuspid valve. ### Claim 8 (depends on 1) The method of claim 1 wherein the outlet fluid is ejected from the bladder through a second valve. ### Claim 9 (depends on 8) The method of claim 8 wherein the second valve is a tricuspid valve. ### Claim 10 (depends on 1) The method of claim 1 wherein the inlet fluid comprises a perfusion solution. ### Claim 11 (depends on 1) The method of claim 1 further comprising extracting umbilical cord blood and/or placenta stem cells using the outlet fluid. ### Claim 12 (depends on 1) The method of claim 1 further comprising providing stem cell therapy using the outlet fluid. ### Claim 13 (depends on 1) The method of claim 1 wherein the inlet fluid comprises blood. ### Claim 14 (depends on 1) The method of claim 1 further comprising providing cardiopulmonary bypass, ventricular assist, extracorporeal membrane oxygenation, organ preservation, fetal cardiac bypass, or cancer treatment using the outlet fluid. ### Claim 15 (depends on 1) The method of claim 1 further comprising preparing the hydraulic actuating sub-assembly for use in the blood pumping method by introducing the pressure transmissive fluid into the fluid chamber through a fill port in an operating shaft, the operating shaft being interconnected and reciprocally moveable with the actuating member. ### Claim 16 (depends on 1) The method of claim 1 further comprising monitoring the position and velocity of a shaft in a communicating motor system, the shaft acting on the actuating member to generate the movement of the actuating member. ### Claim 17 An extracorporeal pumping method comprising: receiving an inlet fluid through a first tricuspid valve into a compressible-expandable bladder sealably mounted within a housing; moving an actuating member mounted within a fluid chamber of a hydraulic actuating sub-assembly, the fluid chamber containing a pressure transmissive fluid, and displacing transmissive fluid from the fluid chamber into the housing; compressing a volume of the bladder in the housing the transmissive fluid displaced into the housing, the compressed bladder ejecting the inlet fluid from the bladder through a second tricuspid valve to provide an outlet fluid under pulsatile pressure; moving the actuating member within the fluid chamber and returning the displaced transmissive fluid from the housing into the fluid chamber; expanding the compressed bladder in the housing and receiving additional inlet fluid into the bladder; programming a predetermined pulse rate, stroke volume, and upstroke rise time into a motion controller, the motion controller controlling pulse rate, stroke volume, and upstroke rise time independently; controlling the movement of the actuating member using the motion controller such that the outlet fluid exhibits the predetermined pulse rate, stroke volume, and upstroke rise time; monitoring the position and velocity of a shaft in a communicating motor system, the shaft acting on the actuating member to generate the movement of the actuating member; and using the outlet fluid under the pulsatile pressure to extract umbilical cord blood and/or placenta stem cells or to provide stem cell therapy, cardiopulmonary bypass, ventricular assist, extracorporeal membrane oxygenation, organ preservation, fetal cardiac bypass, or cancer treatment. ### Claim 18 (depends on 17) The method of claim 17 further comprising programming the predetermined pulse rate, stroke volume, and upstroke rise time into the motion controller using a programmable touch screen. ### Claim 19 (depends on 17) The method of claim 17 further comprising programming the predetermined pulse rate into the motion controller using an EKG trigger. ### Claim 20 (depends on 17) The method of claim 17 wherein using the outlet fluid under the pulsatile pressure comprises extracting umbilical cord blood and/or placenta stem cells.