# US 8,539,989 B2 · Method for the production of pharmaceutical products

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- Number: US 8,539,989 B2
- Document ID: US8539989B2
- Status: Granted
- Kind: B2
- Application number: 12/870,884
- Filed: 2010-08-30
- Published: 2012-03-01
- Granted: 2013-09-24
- Earliest claimed: 2010-08-30
- Assignees: Health Robotics S.R.L.
- Applicants: Paolo Giribona; Walter Bianco; Michele Minisini; Garcia Gaspar de Viedma Santoro
- Inventors: Paolo Giribona; Walter Bianco; Michele Minisini; Garcia Gaspar de Viedma Santoro
- Web page: https://patentgrep.com/patent/US8539989B2

## CPC

- B65B 3/003: {Filling medical containers such as ampoules, vials, syringes or the like}
- A61J 1/10: Bag-type containers
- A61J 3/002: {Compounding apparatus specially for enteral or parenteral nutritive solutions (bottling liquids B67C)}
- B65B: MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING (bundling and pressing devices for cigars A24C1/44; devices for tensioning and securing binders adapted to be supported by the article or articles to be bound B25B25/00; applying closure members to bottles, jars or similar containers B67B1/00-B67B6/00; concurrent cleaning, filling and closing of bottles B67C7/00; emptying bottles, jars, cans, casks, barrels or similar containers B67C9/00)
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE

## Abstract

A method for the preparation of pharmaceutical products according to which a diluent is fed into a container containing a lyophilized or powdered pharmaceutical through a needle, which is then extracted from the container, inserted in its protective cap, and rinsed by feeding the diluent through the needle and into the protective cap itself.

## Claims

### Claim 1

A method for the preparation of pharmaceutical products comprising the steps of:
feeding a container (7) containing a lyophilized or powdered pharmaceutical into a dilution station (75);
inserting a needle (78) into the container (7);
feeding a diluent into the container (7) by means of the needle (78); and
extracting the needle (78) from the container (7);
and characterized in that it further comprises the steps of:
inserting the needle (78) into a protective cap thereof (85); and
feeding the diluent through the needle (78) and into its protective cap (85) to rinse the needle (78) itself.

### Claim 2 (depends on 1)

A method according to claim 1 comprising the following step:
inserting the protective cap (85) in a collection reservoir (82) of the diluent fed through the needle (78).

### Claim 3 (depends on 2)

A method according to claim 2 comprising the step of:
discharging the diluent from the collection reservoir (82) into a collection manifold (83).

### Claim 4 (depends on 3)

A method according to claim 3 comprising the steps of
lowering the collection reservoir (83) to disengage the needle (78) from the protective cap (85); and
lifting the collection reservoir (83) to engage the needle (78) in the protective cap (85).

### Claim 5 (depends on 1)

A method according to claim 1, comprising the steps of:
aspirating the diluent from a containment reservoir (77) by means of a syringe (80); and
feeding the diluent to the needle (78) by means of the syringe (80) itself.

### Claim 6 (depends on 1)

Method according to claim 1, comprising the following step:
rinsing the needle (70) with an amount of diluent sufficient to rinse the protective cap (85) as well.