# US 8,539,948 B2 · Hyperthermia assisted radiation therapy

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- Number: US 8,539,948 B2
- Document ID: US8539948B2
- Status: Granted
- Kind: B2
- Application number: 12/782,323
- Filed: 2010-05-18
- Published: 2010-11-25
- Granted: 2013-09-24
- Earliest claimed: 2009-05-19
- Assignees: William Beaumont Hospital
- Applicants: Dan Ionascu; Brian Marples; Di Yan; Alvaro Martinez
- Inventors: Dan Ionascu; Brian Marples; Di Yan; Alvaro Martinez
- Web page: https://patentgrep.com/patent/US8539948B2

## CPC

- A61F 7/007: {characterised by electric heating}
- A61M 16/026: {specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis}
- A61M 16/1075: {by influencing the temperature (A61M16/1045 takes precedence)}
- A61M 16/16: Devices to humidify the respiration air {(A61M16/1045 takes precedence)}
- A61M 16/161: {with means for measuring the humidity}
- A61N 5/10: X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy (A61N5/01 takes precedence)
- A61F 2007/0019: {Breast}
- A61F 2007/006: {of gas}
- A61F 2007/0061: {Using breath}
- A61F 2007/0096: {with a thermometer}
- A61M 16/0078: {Breathing bags}
- A61M 16/0808: {Condensation traps}
- A61M 16/22: Carbon dioxide-absorbing devices {; Other means for removing carbon dioxide}(cartridges with absorbing substances for respiratory apparatus A62B19/00)
- A61M 2016/0036: {in the breathing tube and used in both inspiratory and expiratory phase}
- A61M 2016/1025: {the O2 concentration}
- A61M 2205/18: with alarm
- A61M 2205/3368: Temperature
- A61M 2205/3606: cooled
- A61M 2205/3673: thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors
- A61M 2230/432: partial CO2 pressure (P-CO2)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A breathing system for hyperthermic assisted radiation therapy includes at least one heating element that modulates the temperature of air inhaled by a patient, at least one cooling element that modulates the humidity of the air inhaled by a patient, and a controller that maintains the desired humidity and temperature.

## Claims

### Claim 1

A method for locally inducing hyperthermia in lung tissue in a patient for radiation therapy comprising:
modulating the temperature of air inhaled by the patient;
modulating the humidity of the air inhaled by the patient;
achieving hyperthermia in the lung tissue of the patient; and
maintaining the humidity and temperature of the air inhaled by the patient.

### Claim 2 (depends on 1)

The method of claim 1 wherein the modulated air temperature inhaled by the patient is between about 45° C. to 55° C.

### Claim 3 (depends on 1)

The method of claim 1 wherein modulating the air temperature induces a thermal steady state in the patient's lung tissue with temperatures in the range of about 41° C. to 43° C.

### Claim 4 (depends on 1)

The method of claim 1 wherein the modulated humidity of the air inhaled by the patient is less than about 65%.

### Claim 5 (depends on 4)

The method of claim 4 wherein the modulated humidity of the air inhaled by the patient is less than about 60%.

### Claim 6 (depends on 1)

The method of claim 1, wherein the temperature is modulated with at least one heating element.

### Claim 7 (depends on 1)

The method of claim 1, wherein the humidity is modulated with at least one Peltier element.

### Claim 8 (depends on 1)

The method of claim 1, wherein the humidity and temperature are maintained with at least one controller.