# US 8,539,944 B2 · Devices and methods for nebulizing fluids for inhalation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,539,944 B2 - Document ID: US8539944B2 - Status: Granted - Kind: B2 - Application number: 12/099,302 - Filed: 2008-04-08 - Published: 2008-08-07 - Granted: 2013-09-24 - Earliest claimed: 2002-01-07 - Assignees: Novartis AG - Applicants: Rajan Patel; Michael A. Klimowicz - Inventors: Rajan Patel; Michael A. Klimowicz - Web page: https://patentgrep.com/patent/US8539944B2 ## CPC - A61M 15/0085: {using ultrasonics (spraying or atomising liquids using ultrasonic vibrations in general B05B17/06)} - A61M 11/005: {using ultrasonics (spraying or atomising liquids using ultrasonic vibrations in general B05B17/06)} - A61M 11/007: {Syringe-type or piston-type sprayers or atomisers} - A61M 15/0065: {Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52)} - A61M 15/0066: {with means for varying the dose size} - B05B 17/0646: {Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto} - A61M 2016/0021: {with a proportional output signal, e.g. from a thermistor} - A61M 2016/0024: {with an on-off output signal, e.g. from a switch} - A61M 2205/50: with microprocessors or computers - A61M 2205/583: by visual feedback - A61M 2205/584: having a color code - A61M 2205/8206: battery-operated - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - B05B: SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES (spray-mixers with nozzles B01F25/72; processes for applying liquids or other fluent materials to surfaces by spraying B05D) ## Abstract A method of delivering a nebulized fluid for inhalation, including providing an aerosol generator, providing a container containing a fluid to be nebulized, providing a reservoir in fluid communication with the container and with the aerosol generator, providing a moveable member positioned to act upon the container in a manner to elect fluid therefrom, providing a linkage mechanism operable through a range of operating positions that is coupled to the moveable member to selectively control a distance of movement of the moveable member, selecting the distance of movement of the moveable member, moving the moveable member to eject fluid from the container into the reservoir, and operating the aerosol generator to elect fluid from the reservoir as a nebulized fluid for inhalation. ## Claims ### Claim 1 A method of delivering a nebulized fluid for inhalation, comprising: providing an aerosol generator; providing a container having a tab and containing a fluid to be nebulized; providing a reservoir assembly having a detent, comprising: a reservoir in fluid communication with the aerosol generator; and a cannula in fluid communication with the reservoir and the container; wherein the reservoir assembly engages the container by interlocking the detent and the tab to hold together the container and the reservoir assembly, providing a moveable member positioned to act upon the container in a manner to eject fluid therefrom; providing a linkage mechanism operable through a range of operating positions that is coupled to the moveable member to selectively control a distance of movement of the moveable member; selecting the distance of movement of the moveable member; moving the moveable member to eject fluid from the container into the reservoir; and operating the aerosol generator to eject fluid from the reservoir as a nebulized fluid for inhalation. ### Claim 2 (depends on 1) The method of claim 1, wherein the container defines a longitudinal axis and the moveable member is moveable in a direction substantially parallel to the longitudinal axis. ### Claim 3 (depends on 1) The method of claim 1, wherein the linkage mechanism comprises: a dosing mechanism, a screw mechanism, and an actuator, wherein the moveable member comprises a plunger, wherein the dosing mechanism, the screw mechanism, the actuator, and the plunger together form a titration mechanism, wherein the plunger is movable along a longitudinal axis within the titration mechanism, wherein the actuator is movable a fixed distance X along the longitudinal axis defined by the plunger, and wherein the dosing mechanism is rotatable in a plane substantially perpendicular to the longitudinal axis; wherein the container comprises a vial mechanism, comprising: a vial, the vial having a longitudinal axis; and a movable seal movable along the longitudinal axis of the vial; and further comprising: inserting the vial mechanism into a housing coupled to the aerosol generator such that the longitudinal axis of the vial is substantially parallel to the longitudinal axis of the plunger; rotating the dosing mechanism to select a dose; operating the screw mechanism, by rotating the dosing mechanism, to set a variable distance of travel Y of the plunger corresponding to the selected dose the proviso that longitudinal travel of the plunger is not imparted; moving the actuator longitudinally the fixed distance X to move the plunger longitudinally the selected variable distance Y to move a movable stopper the variable distance Y; and displacing a volume of liquid, corresponding to the selected dose, from the vial to contact the aerosol generator. ### Claim 4 (depends on 3) The method of claim 3, wherein the aerosol generator comprises: an aerosolization element having a first face and a second face, each face having a plurality of apertures therethrough, wherein operating the aerosol generator comprises vibrating the aerosolization element. ### Claim 5 (depends on 3) The method of claim 3, further comprising coupling the reservoir to the aerosol generator, wherein the volume of liquid is displaced from the vial into the reservoir to contact the aerosol generator. ### Claim 6 (depends on 1) The method of claim 1, wherein the moveable member comprises a longitudinally moveable plunger, movement thereof defining a longitudinal axis, wherein the linkage mechanism comprises: a longitudinally moveable actuator to move the plunger, movement of the actuator being along the longitudinal axis; a screw mechanism to set a distance of travel of the plunger; and a rotatably mounted dosing mechanism, rotation thereof defining an axis of rotation; and wherein the container comprises a vial mechanism, comprising: a vial along the longitudinal axis; and a moveable seal being moveable along the longitudinal axis. ### Claim 7 (depends on 6) The method of claim 6, further comprising: providing a controller to control operation of the aerosol generator; placing the vial mechanism within a housing coupled to the aerosol generator such that the longitudinal axis of the vial is substantially coaxial with the axis of rotation of the dosing mechanism; rotating the dosing mechanism to select a dose; and moving the actuator to move the plunger such that fluid is dispensed from the vial.