Therapeutic methods employing nitric oxide precursors
AssigneeVanderbilt University
InventorsMarshall L. Summar, Brian W. Christman, Frederick E. Barr
Life of this patent
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Abstract
Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.
Claims25
A method of treating a mammal subjected to cardiac surgery comprising intravenously administering to said mammal a therapeutically effective amount of a pharmaceutical composition comprising citrulline.
Dependencies are inferred from the claim text.