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US 8,536,222 B2Granted
Addition compounds of guanidinoacetic acid
AssigneeAlzchem AG
InventorsThomas Gastner, Hans-Peter Krimmer
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AssigneeAlzchem AG
InventorsThomas Gastner, Hans-Peter Krimmer
Estimating the term…
The present invention provides new addition compounds of guanidinoacetic acid with malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, gluconic acid, alpha-ketoglutaric acid, pyroglutamic acid, 3-nicotinic acid, lactic acid, citric acid, maleic acid, acetic acid, formic acid, 2-hydroxybenzoic acid, L-carnitine, acetyl-L-carnitine, taurine, betaine, choline, methionine and lipoic acid as well as in the form of sodium, potassium or calcium guanidinoacetate. These addition compounds have improved physiological and therapeutic properties and are particularly suitable for use as dietary supplements, as animal feeds and in cosmetic or dermatological preparations in which especially the marked stability and good bioavailability of the addition compounds come to the fore.
A method comprising increasing creatine in the muscle of a subject by administering to said subject a composition comprising at least one guanidinoacetic acid addition compound comprising (i) guanidinoacetic acid and (ii) malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, glut acid, alpha-ketoglutaric acid, pyroglutamic acid, 3-nicotinic acid, citric acid, maleic acid, acetic acid, formic acid, 2-hydroxybenzoic acid, L-carnitine, acetyl-L-carnitine, taurine, betaine, choline or lipoic acid.
A method comprising increasing muscle mass of a subject by administering to said subject a composition comprising at least one guanidinoacetic acid addition compound comprising (i) guanidinoacetic acid and (ii) malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, gluconic acid, alpha-ketoglutaric acid, pyroglutamic acid, 3-nicotinic acid, citric acid, maleic acid, acetic acid, formic acid, 2-hydroxybenzoic acid, L-carnitine, acetyl-L-carnitine, taurine, betaine, choline or lipoic acid.
A method comprising increasing the bioavailability of guanidinoacetic acid in a subject by administering to said subject a composition comprising at least one guanidinoacetic acid addition compound comprising (i) guanidinoacetic acid and (ii) malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, gluconic acid, alpha-ketoglutaric acid, pyroglutamic acid, 3-nicotinic acid, citric acid, maleic acid, acetic acid, formic acid, 2-hydroxybenzoic acid, L-carnitine, acetyl-L-carnitine, taurine, betaine, choline or lipoic acid.
An animal feed or dietary supplement comprising at least one guanidinoacetic acid addition compound comprising (i) guanidinoacetic acid and (ii) at least one compound selected from the group consisting of malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, gluconic acid, alpha-ketoglutaric acid, pyroglutamic acid, 3-nicotinic acid, lactic acid, citric acid, maleic acid, acetic acid, formic acid, 2-hydroxybenzoic acid, L-carnitine, acetyl-L-carnitine, taurine, betaine, choline, methionine and lipoic acid.
Dependencies are inferred from the claim text.