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US 8,535,725 B2Granted
Porous-wall hollow glass microspheres as carriers for biomolecules
AssigneesGeorgia Health Sciences University Research Institute, Inc., Savannah River Nuclear Solutions, LLC
InventorsShuyi Li, William S. Dynan, George Wicks, Steven Serkiz
Life of this patent
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Abstract
The present invention includes compositions of porous-wall hollow glass microspheres and one or more biomolecules, wherein the one or more biomolecules are positioned within a void location within the hollow glass microsphere, and the use of such compositions for the diagnostic and/or therapeutic delivery of biomolecules.
Claims15
A hollow microsphere comprising:
- a glass wall surrounding an internal volume to form a glass microsphere having a diameter of about 10 microns to about 100 microns, wherein the glass wall comprises an external surface and an internal surface, and
- dextran-gated channels having a diameter of about 1 nm to about 100 nm connecting the external surface and the internal volume, wherein the internal volume comprises a biopolymer and wherein the dextran-gated channels passively regulate passage of the biopolymer out of the hollow microsphere.
Dependencies are inferred from the claim text.