Apyrase therapy for bleeding conditions
AssigneeAPT Therapeutics, Inc.
InventorsRidong Chen, Soon Seog Jeong
Life of this patent
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Abstract
This invention provides new methods of treating subjects experiencing or at risk of bleeding due to vascular injury, especially to the microvasculature and/or platelet desensitization. Examples of injury usefully treated by apyrase agents are pathophysiological conditions, ischemia reperfusion injury, injury from pharmacologic agents such as anticoagulants, antiplatelet agents, antithrombotics, thrombolytics, and/or immunosuppressants, and injury resulting from transplantation. Apyrase agents are also useful to maintain organ function when said organs are transplanted into an allogeneic recipient.
Claims12
A method to decrease bleeding or the risk of bleeding in a subject which method comprises
- (a) identifying a subject diagnosed as in need of said decrease or at such risk and
- (b) administering to said subject an effective amount of an apyrase agent,
- wherein said subject has suffered or is expected to suffer vascular injury that disrupts the blood vessels of said subject.
A method to preserve the function of a transplanted organ, which method comprises treating the organ to be transplanted or treating a transplant recipient receiving said organ and identified as diagnosed as in need of inhibition of bleeding with an effective amount of an apyrase agent.
Dependencies are inferred from the claim text.