Biodegradable polymer—bioactive moiety conjugates
AssigneePolyactiva Pty Ltd
InventorsMichael Shane O'Shea, Florian Hans Maximilian Graichen, Russell John Tait, Heng Chy Taing, Justine Leigh Jeffery
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Abstract
The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.
Claims30
A biodegradable fluoroquinolone-polymer conjugate which is a polymer of a monomer of formula (II):
- where:
- X′ and Y′ are each terminal reactive functional groups capable of reacting with functional groups of one or more monomers;
- R represents a linear or branched optionally substituted hydrocarbon;
- Z is a spacer moiety;
- and
- D is selected from fluoroquinolone antibiotics;
- with at least one monomer comprising compatible chemical functionality.
A biodegradable fluoroquinolone-polymer conjugate comprising as part of its polymer backbone a plurality of moieties of general formula (I):
- where:
- A and B, which are the same or different, represent the remainder of the polymer backbone and (i) comprise one or more —X—R(ZD)-Y— as shown in formula (I), and (ii) are each formed from monomeric units that are coupled via a biodegradable moiety, wherein each X, Y, R, Z and D in a given —X—R(ZD)-Y— moiety of the biodegradable polymer is the same or different;
- X and Y are each independently selected from an ester and a carbamate moiety;
- R represents a linear or branched optionally substituted hydrocarbon;
- Z is a spacer moiety;
- and
- D is a fluoroquinolone antibiotic.
A monomer-bioactive moiety conjugate that is suitable for use in preparing a biodegradable polymer, the monomer-bioactive moiety conjugate having a structure of general formula (II):
- where:
- X′ and Y′ are each independently functional groups that (a) are capable of undergoing polymerisation with monomer having compatible chemical functionality so as to form a biodegradable polymer, and (b) react with the compatible chemical functionality to afford a biodegradable moiety;
- R represents a linear or branched optionally substituted hydrocarbon;
- Z is a spacer moiety;
- and
- D is a fluoroquinolone antibiotic.
Dependencies are inferred from the claim text.