Spray system and method of making phase separated polymer membrane structures
AssigneeCook Medical Technologies LLC
InventorsKeith R. Milner, Matthew S. Huser
Life of this patent
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Abstract
A spray system and method of using such spray system to fabricate a polymer membrane structure for use as a vascular graft or tissue engineered scaffold is provided. Generally, this spray system includes the use of at least two spray apparatus to apply different polymer and solvent mixtures to the outer surface of a mandrel to form a blended layer. Upon curing of the blended layer, phase separation occurs leading to the formation of a polymer membrane structure having variable properties along at least a portion of its longitudinal axis.
Claims12
A method of fabricating a polymer membrane structure for use as an implantable medical prosthesis, the method comprising:
- providing a first fluid mixture;
- the first fluid mixture being a first polymer material dissolved in a first solvent;
- placing the first fluid mixture in communication with a first spray apparatus;
- providing a second fluid mixture;
- the second fluid mixture being one selected from the group of a second polymer material dissolved in the first solvent;
- the second polymer material dissolved in a second solvent;
- or the second solvent;
- placing the second fluid mixture in communication with a second spray apparatus;
- providing a mandrel having an outer surface and a longitudinal axis;
- applying the first fluid mixture to at least a portion of the outer surface of the mandrel by spraying said fluid mixture from the first spray apparatus;
- applying the second fluid mixture to at least a portion of the outer surface of the mandrel by spraying said fluid mixture from the second spray apparatus, such that the second fluid mixture contacts the first fluid mixture;
- allowing the second fluid mixture to interact with the first fluid mixture on the outer surface of the mandrel until a blended layer is formed;
- curing the blended layer;
- wherein during said curing, the blended layer undergoes phase separation to form a polymer membrane structure on the outer surface of the mandrel;
- and
- removing the polymer membrane structure from the outer surface of the mandrel;
- the polymer membrane having a defined thickness and length.
Dependencies are inferred from the claim text.