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US 8,530,441 B2Granted
Transgene delivering retrovirus targeting collagen exposed at site of tissue injury
AssigneeUniversity of Southern California
InventorsFrederick L. Hall, Erlinda M. Gordon
Life of this patent
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Abstract
A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.
Claims12
A method of treating or repairing a site of tissue injury of a host, comprising:
- directly or intravenously delivering to the site of tissue injury of the host a viral particle comprising:
- i) a modified viral envelope protein wherein the viral envelope protein includes a receptor binding region, wherein the receptor binding region is modified to include a collagen binding domain, and
- ii) at least one polynucleotide encoding a therapeutic polypeptide operably linked to a promoter, wherein said therapeutic protein is able to treat or promote repair in said site of tissue injury,
- wherein the viral particle binds to collagen exposed at the site of tissue injury and expresses the therapeutic polypeptide at the site of tissue injury, whereby the site of tissue injury is treated or repaired.
1 more element
A method of treating a tumor of a host, comprising:
- directly or intravenously delivering to the site of the tumor of the host a retroviral particle comprising:
- i) a modified viral envelope protein wherein the viral envelope protein includes a receptor binding region, wherein the receptor binding region is modified to include a collagen binding domain, and
- ii) at least one polynucleotide encoding a therapeutic polypeptide operably linked to a promoter, wherein said therapeutic protein is able to treat said tumor,
- wherein the viral particle binds to collagen exposed at the tumor and expresses the therapeutic polypeptide at the site of tumor, whereby the tumor is treated.
1 more element
Dependencies are inferred from the claim text.