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US 8,530,427 B2Granted
Methods for modulating resistance to apoptosis using KLK6
AssigneeMayo Foundation for Medical Education and Research
InventorIsobel A. Scarisbrick
Life of this patent
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Abstract
This document provides methods and materials involved in modulating a cell's ability to be resistant to apoptosis. For example, methods and materials for exposing cells to KLK6 polypeptides, or increased KLK6 polypeptide activity, to promote resistance to apoptosis are provided. In addition, methods and materials for reducing the ability of KLK6 polypeptides to promote resistance to apoptosis are provided.
Claims5
A method for treating a mammal having a condition wherein cells undergo excessive apoptosis, wherein said method comprises:
- (a) identifying a mammal as being in need of a reduction in excess apoptosis of cells of a cell type selected from the group consisting of lymphocytes, splenocytes, monocytes, oligodendrocytes, astrocytes, neurons, glia, epidermal cells, and stem cells, and
- (b) administering a Kallikrein 6 (KLK6) polypeptide to said mammal under conditions wherein said KLK6 polypeptide contacts said cells prior to or at the same time that said cells receive an apoptosis inducing stimulus and reduces the level of apoptosis of said cells.
Dependencies are inferred from the claim text.