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US 8,528,589 B2Granted
Manipulation of microfluidic droplets
AssigneeRaindance Technologies, Inc.
InventorsBenjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Link, Mark Weary
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Abstract
The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
Claims9
A method for manipulating microfluidic droplet pairing ratios comprising:
- providing a microfluidic system comprising at least one microfluidic channel;
- providing a first plurality of fluidic droplets within said microfluidic channel at a first frequency;
- providing a second plurality of fluidic droplets within said microfluidic channel at a second frequency, wherein at least one fluidic droplet from said first plurality and at least one fluidic droplet from said second plurality are paired;
- assessing said first frequency and said second frequency using an image sensor;
- and
- transmitting said assessment of said first and said second frequencies to a feedback controller;
- wherein said feedback controller adjusts a flow rate of one or more fluids to provide a desired frequency ratio of said first to said second plurality of droplets, thereby manipulating the pairing ratios of said first and second pluralities of fluidic droplets within said microfluidic channel.
4 more elements
Dependencies are inferred from the claim text.