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US 8,527,250 B2Granted
Method and apparatus for assessing feasibility of probes and biomarkers
AssigneeGeneral Electric Company
InventorsJohn Frederick Graf, Brion Daryl Sarachan, Mary Elizabeth Spilker
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Abstract
The quantitative evaluation of biomarker-probe activity is disclosed. In certain embodiments, the biomarker-probe activity may be quantified and analyzed using biodistributions generated using a model. In some embodiments, such biodistributions may be used to generate simulated images from which quantitative thresholds may be derived. In some embodiments, the quantitative thresholds may be used to analyze the biodistributions.
Claims16
A method, comprising the steps of:
- generating, on a computer, one or more biodistributions representing biomarker-probe activity using a physiological based pharmacokinetics (PBPK) model based at least on inputs of a location of a biomarker, a concentration of the biomarker, and a change in the location or concentration of the biomarker during disease progression;
- generating, on a computer, one or more simulated images based on the one or more biodistributions and a digital phantom;
- and
- quantitatively analyzing, on a computer, the one or more simulated images to derive one or more numeric classifications of biomarker-probe usefulness for imaging.
1 more element
A method, comprising the steps of:
- generating, on a computer, one or more numeric thresholds for a biomarker-probe based on simulated images, wherein each simulated image is generated using a corresponding biodistribution of a plurality of biodistributions, and the plurality of biodistributions is generated using a model that is provided inputs of a location of a biomarker, a concentration of the biomarker, and a change in the location or concentration of the biomarker during disease progression;
- and
- analyzing, on a computer, some or all of the plurality of biodistributions using the one or more numeric thresholds.
Dependencies are inferred from the claim text.