Device and method for determining analyte levels
AssigneeDexCom, Inc.
InventorsMark C. Shults, Stuart J. Updike, Rathbun K. Rhodes
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Abstract
Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
Claims66
A device for measuring a glucose concentration in a host, the device comprising:
- a sensor operably connected to an electronic circuit and configured to continuously measure a signal associated with a glucose concentration in a host;
- and
- a membrane located over at least a portion of the sensor, wherein the membrane is configured to control a flux of oxygen and glucose, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, and wherein the membrane comprises a silicone-containing polymer;
- wherein the device is capable of exhibiting, at a glucose concentration of 400 mg/dL, no more than a 10% drop in sensor output over a range of pO2 from about 150 mm Hg down to about 30 mm Hg.
A device for measuring a glucose concentration in a host, the device comprising:
- a sensor operably connected to an electronic circuit and configured to continuously measure a signal associated with a glucose concentration in a host;
- and
- a membrane located over at least a portion of the sensor, wherein the membrane is configured to control a flux of oxygen and glucose;
- wherein at least 95% of glucose concentration values measured by the device are within 25% of corresponding values determined by analysis of blood over a time period of at least two days.
A device for measuring a glucose concentration in a host, the device comprising:
- an electrode surface operably connected to an electronic circuit and configured to continuously measure in vivo a signal associated with a glucose concentration in a host;
- and
- a membrane located over at least a portion of the electrode surface, wherein the membrane is configured to control a flux of oxygen and glucose;
- wherein at least 95% of glucose concentration values measured by the device are within 25% of corresponding values determined by analysis of blood over a time period of at least 2 days.
Dependencies are inferred from the claim text.