Electrically conductive polymer nanowires with incorporated viruses
AssigneeThe Regents of the University of California
InventorsGregory A. Weiss, Reginald M. Penner, Jessica A. Arter, David K. Taggart, Keith C. Donavan
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Abstract
Grafting M13 bacteriophage into an array of poly(3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and replicable genetic packages (rgps) such as viruses. The incorporation of rgps into the polymeric backbone of PEDOT occurs during electropolymerization via lithographically patterned nanowire electrodeposition (LPNE). The resultant arrays of rgps-PEDOT nanowires enable real-time, reagent-free electrochemical biosensing of analytes in physiologically relevant buffers.
Claims22
A method of making a biosensor comprising:
- depositing a metallic film on a substrate;
- coating the metallic film with a photoresist;
- patterning the photoresist to define desired portions of nanowires;
- removing portions of the exposed metallic film, wherein said removal includes the formation of side-exposed trenches underlying portions of the photoresist;
- electrodepositing virus-PEDOT nanowires in the side-exposed trenches;
- removing the photoresist;
- and
- removing any remaining metallic film.
A biosensor comprising:
- a substrate;
- a plurality of virus-PEDOT nanowires disposed atop the surface of the substrate;
- and
- a resistance measuring device operatively coupled to the plurality of virus-PEDOT nanowires.
Dependencies are inferred from the claim text.