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US 8,524,951 B2Granted
Process for production of hydroxyadamantaneamine
AssigneeShionogi & Co., Ltd.
InventorHideaki Watanabe
Life of this patent
Estimating the term…
Abstract
Disclosed is a process for producing 1-hydroxy-4-aminoadamantane.
Claims6
A process for producing a compound represented by the formula (III) comprising separating a compound represented by the formula (III):
- (wherein R1 and R2 are each independently hydrogen, halogen, carboxy, nitro, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted alkylsulfonyl, optionally substituted arylsulfonyl, or optionally substituted sulfamoyl, or R1 and R2, when a binding carbon atom is adjacent, may be taken together with an adjacent carbon atom to form an optionally substituted ring)
- from a compound represented by the formula (II):
- (wherein R1 and R2 are each independently hydrogen, halogen, carboxy, nitro, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted alkylsulfonyl, optionally substituted arylsulfonyl, or optionally substituted sulfamoyl, or R1 and R2, when a binding carbon atom is adjacent, may be taken together with an adjacent carbon atom to form an optionally substituted ring).
A compound represented by the formula (II):
- (wherein R1 and R2 are each independently hydrogen, halogen, carboxy, nitro, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted alkylsulfonyl, optionally substituted arylsulfonyl, or optionally substituted sulfamoyl, or R1 and R2, when a binding carbon atom is adjacent, may be taken together with an adjacent carbon atom to form an optionally substituted ring)
- or a salt thereof.
A compound represented by the formula (III):
- (wherein R1 and R2 are each independently hydrogen, halogen, carboxy, nitro, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted alkylsulfonyl, optionally substituted arylsulfonyl, or optionally substituted sulfamoyl, or R1 and R2, when a binding carbon atom is adjacent, may be taken together with an adjacent carbon atom to form an optionally substituted ring)
- or a salt thereof.
A crystal of a compound represented by the formula (III):
- (wherein R1 and R2 are each independently hydrogen, halogen, carboxy, nitro, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted alkylsulfonyl, optionally substituted arylsulfonyl, or optionally substituted sulfamoyl, or R1 and R2, when a binding carbon atom is adjacent, may be taken together with an adjacent carbon atom to form an optionally substituted ring)
- or a salt thereof.
Dependencies are inferred from the claim text.