Acylsulfonamides and processes for producing the same
AssigneesUniversity of South Florida, H. Lee Moffitt Cancer Center and Research Institute, Inc.
InventorsHong-Gang Wang, Roman Manetsch, Xiangdong Hu, Sameer Kulkarni, Jiazhi Sun
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Abstract
The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.
Claims19
A process for the preparation of an acylsulfonamide (3), the process comprising reacting a thioacid (1) with a sulfonyl azide (2) in the presence of a protein of the Bcl-2 family, wherein the thioacid (1), the sulfonyl azide (2), and the acylsulfonamide (3) correspond to Formulae (1), (2), and (3):
- Z1 is hydrocarbyl, substituted hydrocarbyl, heteroaryl, or heterocyclo;
- and
- Z2 is hydrocarbyl, substituted hydrocarbyl, heteroaryl, or heterocyclo.
Dependencies are inferred from the claim text.