Nitro group-containing ether compound and method for producing same
AssigneeNational University Corporation Okayama University
InventorsTeruhiko Ishikawa, Seiki Saito, Takayuki Kudoh, Kotaro Suto, Hironori Nishiuchi, Makoto Okada, Masatoshi Taniguchi
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Abstract
It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4c): (wherein R1, R2 and R6 are same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously).
Claims4
A nitro group-containing ether compound of the formula (1)
- wherein R1, R2 and R6 are the same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously.
A process for preparing a compound of the formula (1) comprising subjecting a compound of the formula (2) to intramolecular nitroaldol reaction,
- wherein R1, R2 and R6 are the same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously.
A process for preparing a compound of the formula (3) comprising reducing a compound of the formula (1),
- wherein R1, R2 and R6 are the same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously.
Dependencies are inferred from the claim text.