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US 8,524,914 B2Granted
Method for preparing rosuvastatin, intermediate compounds useful for preparing same, and method for preparing same
AssigneeChong Kun Dang Pharmaceutical Corp.
InventorsHongwoo Lee, Daejong Park, Choongleol Yoo, Donghyuk Nam, Hohyung Ryu, Dongjin Kim
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Abstract
The present invention relates to novel intermediate compounds used in preparing Rosuvastatin or the pharmaceutically acceptable salts thereof, to a method for preparing same, and to a method for preparing Rosuvastatin or the pharmaceutically acceptable salts thereof from the intermediates. The preparation method of the present invention has the effect of providing Rosuvastatin hemi-calcium salts with an excellent yield rate.
Claims5
A method for preparing a compound of formula 3, comprising:
- reacting a compound of formula 1:
- wherein:
- R1 represents
- Y represents a nitrogen or sulfur atom;
- and
- R1a represents hydrogen, C1-C4 alkyl or phenyl
- with a compound of formula 2:
- in the presence of a base to prepare the compound of formula 3:
5 more elements
A compound of Formula 1:
- wherein:
- R1 represents
- Y represents a nitrogen or sulfur atom;
- and
- R1a represents hydrogen, C1-C4 alkyl or phenyl.
2 more elements
Dependencies are inferred from the claim text.