Process for production of α-trifluoromethyl-β-substituted-β-amino acid

A process of producing a α-trifluoromethyl-β-substituted-β-amino acid represented by formula [4]

• comprising:
• allowing a α-trifluoromethyl-β-substituted-α,β-unsaturated ester represented by formula [1]
• to react with a hydroxylamine represented by formula [2]
• H2N—OH [2]
• to convert the α-trifluoromethyl-β-substituted-α,β-unsaturated ester into a dehydrogenated closed-ring body of the α-trifluoromethyl-β-substituted-β-amino acid represented by formula [3]
• to react with a hydroxylamine represented by formula [2]
• H2N—OH [2]
• to convert the α-trifluoromethyl-β-substituted-α,β-unsaturated ester into a dehydrogenated closed-ring body of the α-trifluoromethyl-β-substituted-β-amino acid represented by formula [6]
• and
• hydrogenolyzing the dehydrogenated closed-ring body, wherein, in the formulae,
• R3 is an alkyl group or a substituted alkyl group;
• R4 is an alkyl group;
• the wavy line in formula [5] indicates that the stereochemistry of the double bond is E, Z or a mixture of E and Z;
• the representation of the relative configuration in formula [6] indicates that the stereochemistry of R3 to the trifluoromethyl group is anti;
• and
• and hydrogenolyzing the dehydrogenated closed-ring body, wherein, in the formulae,
• R1 is an alkyl group, a substituted alkyl group, an aromatic ring group, a substituted aromatic ring group, an alkoxycarbonyl group or a substituted alkoxycarbonyl group;
• R2 is an alkyl group or a substituted alkyl group;
• the wavy line in formula [1] indicates that the stereochemistry of the double bond is E, Z or a mixture of E and Z;
• and
• the wavy line in formula [3] and in formula [4] indicates that the stereochemistry of R1 to the trifluoromethyl group is syn, anti, or a mixture of syn and anti.