3-arylamino pyridine derivatives

A compound of formula (II),

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R1, R2, R9, R10, R11, R12, R13 and R14 are independently selected from hydrogen, halogen, cyano, nitro, azido, —OR3, —NR4C(O)OR6, —OC(O)R3, —NR4S(O)jR6, —S(O)jNR3R4, —S(O)jNR4C(O)R3, —C(O)NR4S(O)jR6, S(O)jR6, —NR4C(O)R3, —C(O)NR3R4, —NR5C(O)NR3R4, —NR5C(NCN)NR3R4, —NR3R4, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C3-C10 cycloalkylalkyl or —S(O)j(C1-C6 alkyl);
• provided that R12 is not OH, and R13, R14 are not C1-C10 alkyl;
• R3 is selected from hydrogen, trifluoromethyl, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl or C3-C10 cycloalkylalkyl, where each alkyl, alkenyl, alkynyl and cycloalkyl is unsubstituted or substituted with primary amino, aminocarbonyl, carboxyl, cyano, halogen, hydroxy, nitro or trihalomethyl;
• R4 is selected from hydrogen or C1-C6 alkyl, whereby alkyl may be unsubstituted or substituted with primary amino, aminocarbonyl, carboxyl, cyano, halogen, hydroxy, nitro or trihalomethyl;
• R5 is selected from hydrogen or C1-C6 alkyl, whereby alkyl may be unsubstituted or substituted with primary amino, aminocarbonyl, carboxyl, cyano, halogen, hydroxy, nitro or trihalomethyl;
• R6 is selected from trifluoromethyl, C1-C10 alkyl or C3-C10 cycloalkyl;
• W is selected from —C(O)OR15, —C(O)NR4R15, —C(O)NR4OR15, —C(O)NR4S(O)jR6, —C(O)NR4NR4R15, —NR′C(O)R′, —NR′S(O)jR′, —NRC(O)NR′R″, NR′S(O)jNR′R″ or —C(O)NR4NR4C(O)R15;
• provided that W is not C(O)OH;
• R15 is independently selected from hydrogen, trifluoromethyl, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C3-C10 cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, where each alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl is unsubstituted or substituted with primary amino, aminocarbonyl, carboxyl, cyano, halogen, hydroxy, nitro, trihalomethyl, O—C1-C4 alkyl or NR′R″;
• R′ and R″ are independently selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, aryl or arylalkyl;
• X is N or N+O−;
• and
• j is 1 or 2, with the proviso that 3-Phenylamino-isonicotinic acid methyl ester and 3-Oxo-3-(3-phenylamino-pyridin-4-yl)-propionic acid ethyl ester are not included.