Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
AssigneeAlmirall, S.A.
InventorsIolanda Marchueta Hereu, Enrique Moyes Valls
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Abstract
A process for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof, which process comprises: a) reacting, in a xylene solvent, a compound of formula (V) having P1 and P2 protecting groups, with a compound of formula (IV), to give a compound of formula (III); and b) effecting a P1 deprotection step and a P2 deprotection step to give a compound of formula (I); and optionally c) preparing a pharmaceutically acceptable salt of a compound of formula (I); wherein the compounds of formulas III, IV, and V are described in the specification.
Claims16
A process for preparing a compound of formula (I)
- or a pharmaceutically acceptable salt thereof,
- the process comprising:
- a) reacting, in a xylene solvent, a compound of formula (V)
- wherein P1 and P2 represent hydroxy protecting groups, which are the same or different, and L is a leaving group,
- with 6-(2,2-difluoro-2-phenylethoxy)hexan-1-amine of formula (IV),
- to give a compound of formula (III)
- b) effecting a P1 deprotection step and a P2 deprotection step, to remove the protecting groups P1 and P2 and give a compound of formula (I);
- and
- c) optionally preparing a pharmaceutically acceptable salt of a compound of formula (I).
Dependencies are inferred from the claim text.