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US 8,524,905 B2Granted
Processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, a novel intermediate for the synthesis of PDE IV inhibitors
AssigneeGlenmark Pharmaceuticals S.A.
InventorsLaxmikant Atmaram Gharat, Jitendra Maganbhai Gajera, Sandip Damodar Patil, Suresh M. Kadam
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Abstract
The present invention relates to novel processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, which is a novel and useful intermediate for preparing compounds with PDE4 inhibitory activity, such as 3,5-dichloro-4-(6-difluoromethoxybenzo[4,5]furo[3,2-c]pyridin-9-ylcarboxamido)-1-pyridiniumolate.
Claims5
A pharmaceutical composition comprising:
- (a) a compound of the formula
- or a pharmaceutically acceptable salt thereof;
- and
- (b) a compound selected from
- or a salt thereof, wherein
- P is selected from an optionally substituted benzyl, alkyl, halogenated alkyl, cycloalkyl, cycloalkylalkyl, silyl, allyl, propargyl, tetrahydropyran, alkoxyalkyl and silyloxyalkyl, and
- the compound in component (a) is present in an amount greater than 98% by weight and the compound in component (b) is present in an amount up to 0.1% by weight, based upon 100% total weight of components (a) and (b).
4 more elements
A compound selected from:
- or a salt thereof,
- wherein:
- P is selected from an optionally substituted benzyl, alkyl, halogenated alkyl, cycloalkyl, cycloalkylalkyl, silyl, allyl, propargyl, tetrahydropyran, alkoxyalkyl and silyloxyalkyl.
A composition comprising:
- (a) a compound of the formula
- or a pharmaceutically acceptable salt thereof;
- and
- (b) a compound selected from
- or a salt thereof, wherein P is selected from an optionally substituted benzyl, alkyl, halogenated alkyl, cycloalkyl, cycloalkylalkyl, silyl, allyl, propargyl, tetrahydropyran, alkoxyalkyl and silyloxyalkyl.
2 more elements
Dependencies are inferred from the claim text.