Alternative heterocycles for DNA recognition
AssigneeCalifornia Institute of Technology
InventorsPeter B. Dervan, Christoph A. Briehn, Dorte Renneberg, Philipp Weyermann, Raymond Doss, Michael Marques
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Abstract
Methods and compositions are provided for forming complexes between dsDNA and novel oligomers comprising fused six-membered rings. By appropriate choice of target sequences and oligomers, complexes comprising oligomer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.
Claims13
An oligomer or a pharmaceutically acceptable salt thereof, wherein said oligomer is selected from the group consisting of:
- Oligomer
- Name
- Oligomer Structure
- A
- B
- C
- D
- E
- F
- G
- I
- J
- K
- L
An oligomer or a pharmaceutically acceptable salt thereof, wherein said oligomer is
Dependencies are inferred from the claim text.