Method for preparing amide
AssigneeChina Petrochemical Development Corporation
InventorsTung-Han Tsai, Pin-To Yao, Cheng-Fa Hsieh
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Abstract
The present invention provides a method for preparing amides, in which an amino acid ionic liquid is used as both a reaction medium and a catalyst to catalyze Beckman rearrangement of a ketoxime, so as to produce an amide. In the method, the rearrangement is conducted by catalyzing a ketoxime with an amino acid ionic liquid having the asymmetric property at a moderate reaction temperature during a short reaction time, so as to produce an amide without adding other catalysts such as concentrate sulfuric acid. The method has advantages such as avoiding corrosion in equipments with pipelines, the high conversion rate of ketoximes and the high selectivity of amides.
Claims16
A method for preparing an amide, comprising the steps of:
- catalyzing Beckman rearrangement of a ketoxime to produce an amide in the presence of a catalyst,
- wherein the catalyst is an N-substituted amino acid ionic liquid having a cation represented by the following formula (I) and one or more anions selected from the group consisting of inorganic acid ions, organic acid ions and a combination thereof:
- wherein R1 is hydrogen, cycloimino, or C1-C8alkyl, in which the C1-C8alkyl is unsubstituted or substituted by a substituent selected from the group consisting of hydroxyl (—OH), carboxyl (—COOH), guanidino (NH2C(═NH)NH—), amino (—NH2), amido (RCONH—), hydroxyphenyl, C1-C8alkylthio, thiol (—SH), C6-C10aryl and 5- to 10-membered heteroaryl;
- and
- R2 and R3 are independently hydrogen or C1-C8alkyl, in which the C1-C8alkyl is unsubstituted or substituted by a substituent selected from the group consisting of carboxyl (—COOH), sulfo (—SO3H), chlorosulfinyl (ClSO—), ester group (—COOR, wherein R is C1-C8alkyl), oxo (═O) and C6-C10aryl, provided that R2 and R3 are not hydrogen concurrently,
- wherein the numbers of the anion and the cation are such that the N-substituted amino acid ionic liquid is electroneutral.
Dependencies are inferred from the claim text.