Hydrazido derivatives of hyaluronic acid
AssigneesProChon Biotech Ltd., Bio-Technology General (Israel) Ltd.
InventorsBoaz Amit, Avraham Wortzel, Avner Yayon
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Abstract
Disclosed are chemically modified hyaluronic acid (HA) derivatives containing hydrazido groups directly linked to the glucuronic acid residues of HA. Said hydrazido groups are used to obtain crosslinked and labeled HA derivatives. The invention further relates to methods of preparation of said HA derivatives.
Claims16
A hyaluronic acid (hereinafter HA) derivative or a salt thereof, said derivative having a part of the carboxy groups of the D-glucuronic residues converted directly into hydrazido groups between pH 5.7 and pH 5.9, wherein said hyaluronic acid derivative is an uncross-linked, water-soluble compound represented by the formula HA-CO-NH-NH2 having not less than 10% hydrazido groups.
Dependencies are inferred from the claim text.