RNAi molecule targeting thymidylate synthase and application thereof
AssigneeDelta-Fly Pharma, Inc.
InventorsHiromi Wada, Cheng Long Huang
Life of this patent
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Abstract
This invention provides a novel RNAi molecule that can significantly potentiate antitumor effects of a 5-FU antitumor agent. The RNAi molecule comprises the nucleotide sequence shown in SEQ ID NO: 2. The invention also provides an antitumor agent comprising such RNAi molecule and a 5-FU antitumor agent.
Claims15
An RNAi molecule capable of suppressing expression of thymidylate synthase by RNAi action comprising a double-stranded RNA domain, which consists of the nucleotide sequence represented by SEQ ID NO:
- 8.
A vector comprising template DNA of an RNAi molecule which consists of the nucleotide sequence represented by SEQ ID NO:
- 8 and which expresses the RNAi molecule.
Dependencies are inferred from the claim text.