Anti-platelet membrane glycoprotein VI monoclonal antibody
AssigneeMochida Pharmaceutical Co., Ltd.
InventorsHiroshi Takayama, Kamon Shirakawa, Shoji Furusako, Yoshitaka Hosaka, Tomokazu Matsusue, Katsuki Naitoh, Yumi Hotta, Tetsushi Kawahara, Motoyasu Honda
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Abstract
The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
Claims8
An isolated antibody or antigen-binding fragment thereof that specifically binds to loop 9 in domain 2 of human platelet glycoprotein VI (GPVI),
- wherein said antibody or antigen-binding fragment thereof comprises a variable heavy chain (VH) with 3 complementarity determining regions (CDR) and a variable light chain (VL) with 3 complementarity determining regions (CDR), comprising the following VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2, and VL CDR3, respectively of:
- (i) SEQ ID NOs:
- 335, 336, 337, 377, 378 and 379;
- (ii) SEQ ID NOs:
- 344, 345, 346, 386, 387 and 388;
- (iii) SEQ ID NOs:
- 347, 348, 349, 389, 390 and 391;
- (iv) SEQ ID NOs:
- 356, 357, 358, 398, 399, and 400;
- or
- (v) SEQ ID NOs:
- 371, 372, 373, 413, 414, 415.
Dependencies are inferred from the claim text.