Humanized antibodies against LIGHT and uses thereof
AssigneeTeva Biopharmaceuticals USA, Inc.
InventorsRodger Smith, Palanisamy Kanakaraj, Bridget A. Cooksey, Viktor Roschke, Craig Rosen
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Abstract
The present invention is directed to antigen-binding polypeptides, or variants or derivatives thereof which specifically bind the LIGHT polypeptide. The invention is also directed to methods of making and using such antibodies specifically in the treatment or diagnosis of immune, inflammatory and malignant diseases or conditions (e.g. inflammatory bowel disease; Crohn's disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis and transplantation).
Claims19
An antigen-binding polypeptide which specifically binds to the LIGHT polypeptide, wherein the polypeptide comprises a humanized heavy chain variable region comprising:
- (1) a CDR-H1 comprising the amino acid sequence SYYIH (SEQ ID NO:23),
- (2) a CDR-H2-comprising the amino acid sequence WIFPGSDITKYNEKFKG (SEQ ID NO:24), and
- (3) a CDR-H3 comprising the amino acid sequence EDYGISTYSAMDF (SEQ ID NO:25).
Dependencies are inferred from the claim text.