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US 8,524,867 B2Granted
Optimized antibodies that target CD19
AssigneeXencor, Inc.
InventorsMatthew J. Bernett, Seung Yup Chu, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, Erik WeiKing Pong, John O. Richards, Eugene Alexander Zhukovsky
Life of this patent
Estimating the term…
Abstract
Antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody, and methods of using the antibodies.
Claims32
An antibody that binds CD19, said antibody comprising a heavy chain and a light chain, said heavy chain comprising a variable region having a CDR1 comprising SEQ ID NO:
- 132, a CDR2 comprising SEQ ID NO:
- 147, and a CDR3 comprising SEQ ID NO:116;
- and said light chain comprising a variable region having a CDR1 comprising SEQ ID NO:
- 120, a CDR2comprising SEQ ID NO:129, and a CDR3 comprising SEQ ID NO:130, wherein the heavy chain comprises an Fc domain comprising an amino acid substitution at position S239 and/or 1332, wherein the numbering is according to the EU index as in Kabat.
1 more element
Dependencies are inferred from the claim text.