Antibodies to the alpha-7 nicotinic receptors and methods of treating inflammatory disorders with the same
AssigneeThe Feinstein Institute for Medical Research
InventorsLihong Yang, Kevin J. Tracey
Life of this patent
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Abstract
An antibody or an antigen binding fragment thereof which binds to mammalian α7 subunit of a nicotinic acetylcholine receptor or its functional variant and which is an agonist of said receptor or variant. Pharmaceutical compositions comprising same. A method of treating a subject suffering from an inflammatory condition comprising administering to said subject an antibody or an antigen-binding fragment as described herein.
Claims33
An isolated antibody or an antigen-binding fragment thereof that specifically binds to a 20 amino acid peptide consisting of an amino acid sequence at least 90% identical to SEQ ID NO:2, 100% identical to SEQ ID NO:3, or at least 80% identical to SEQ ID NO:4.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and an antibody or an antigen-binding fragment thereof that specifically binds to a 20 amino acid peptide consisting of an amino acid sequence at least 90% identical to SEQ ID NO:2, 100% identical to SEQ ID NO:3, or at least 80% identical to SEQ ID NO:4.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and an antibody or an antigen-binding fragment thereof that specifically binds to a peptide consisting of SEQ ID NO:2.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and an antibody or antigen-binding fragment thereof that specifically binds to a peptide consisting of SEQ ID NO:3.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and an antibody or antigen-binding fragment thereof that specifically binds to a peptide consisting of SEQ ID NO:4.
A method of treating a subject suffering from a cytokine-mediated inflammatory condition, wherein the level of cytokine release can be reduced by alpha-7 receptor activation, comprising:
- administering to said subject an effective amount of an antibody or an antigen-binding fragment thereof,
- wherein the antibody or the antigen-binding fragment specifically binds to a 20 amino acid peptide consisting of an amino acid sequence at least 90% identical to SEQ ID NO:2, 100% identical to SEQ ID NO:3, or at least 80% identical to SEQ ID NO:4, wherein the condition is selected from peritonitis, pancreatitis, sepsis, endotoxic shock, Crohn's disease, ulcerative colitis, adult respiratory distress syndrome, rheumatoid arthritis or asthma.
A method of treating a subject suffering from sepsis, comprising
- administering to said subject an effective amount of an antibody or an antigen binding fragment thereof,
- wherein said antibody or antigen-binding fragment specifically binds a peptide consisting of SEQ ID NO:2, thereby treating the sepsis.
Dependencies are inferred from the claim text.