Treatment of bacterial infections
AssigneeAi2 Limited
InventorsCurtis Dobson, Keith Alan Crutcher
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Abstract
The invention relates to polypeptides, comprising repeats of peptides derived from apolipoproteins, which exhibit antibacterial activity and to nucleic acids encoding the same. The invention further provides the use of such polypeptides, derivatives, analogues or nucleic acids as medicaments, and also their use in methods of preventing or treating bacterial infection or objects and surfaces. The invention further extends to objects, such as contact lenses, coated with the polypeptides.
Claims29
A method of treating a bacterial infection in a subject, comprising:
- providing a composition comprising a polypeptide and a pharmaceutically acceptable vehicle,
- wherein the polypeptide comprises a tandem dimer repeat of a nonapeptide selected from the group consisting of:
- SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:96, or the polypeptide comprises a tandem repeat of the nonapeptide wherein at least one amino acid residue, other than RKR motifs, of the polypeptide is replaced by an Arginine (R), Tyrosine (Y), Methionine (M), Isoleucine (I), Phenylalanine (F), Tryptophan (W);
- and
- administering said composition to said subject.
A method of treating a bacterial infection in a subject, comprising:
- providing a composition comprising a polypeptide comprising a repeat of the peptide apoE141-149 (SEQ ID NO:1), or a repeat of a variant or peptide apoE141-149 in which at least one Leucine (L) residue is replaced by Tryptophan (W), Arginine (R), Lysine (K), Tyrosine (Y) or Phenylalanine (F), and a pharmaceutically acceptable vehicle;
- and
- administering said composition to said subject.
A method of treating a bacterial infection in a subject, comprising:
- providing a composition comprising a polypeptide and a pharmaceutically acceptable vehicle, wherein the polypeptide has the sequence of RLTRKRGLKRLTRKRGLK (SEQ ID NO:12) wherein at least one amino acid residue, other than the RKR mot has been replaced by a Glycine (G), Threonine (T), Histidine (H), Tryptophan (W), Arginine (R) or Leucine (L) residue;
- and
- administering said composition to said subject.
A method of reducing the likelihood of and/or treating bacterial contamination comprising:
- providing a composition comprising a polypeptide and a pharmaceutically acceptable vehicle, wherein the polypeptide comprises a tandem dimer repeat of a nonapeptide selected from the group consisting of:
- SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:96, or the polypeptide comprises a tandem repeat of the nonapeptide wherein at least one amino acid residue, other than RKR motifs, of the polypeptide is replaced by an Arginine (R), Tyrosine (Y), Methionine (M), Isoleucine (I), Phenylalanine (F), Tryptophan (W);
- and
- coating an object or a surface in need thereof with an amount of said composition in an amount effective for killing bacteria or reducing the growth of bacteria.
Dependencies are inferred from the claim text.