Peptides with capacity to bind to scurfin and applications
AssigneeProyecto De Biomedicina Cima, S.L.
InventorsInés Noelia Casares Lagar, Francisco Borrás Cuesta, Pablo Sarobe Ugarriza, Jesús Maria Prieto Valtueña, Juan José Lasarte Sagastibelza
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Abstract
The invention relates to peptides of general formula (I), wherein X is absent or X is present and is X14 or X14-X15, wherein X14 and X15, independently from one another, represent an amino acid; their functional variants and fragments, and their pharmaceutically acceptable salts, having the capacity to bind to scurfin and inhibit its biological activity, therefore they regulate or block the activity of regulatory T (Treg) lymphocytes. They are applicable in the treatment of infectious and neoplastic diseases. (I) Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe- Phe-X
Claims16
An isolated peptide with capacity to bind to scurfin, selected from the group consisting of:
- a peptide set forth in SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 18, and SEQ ID NO:
- 19;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.