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US 8,524,829 B2Granted
Methods for micronization of hydrophobic drugs
AssigneeBrown University Research Foundation
InventorsEdith Mathiowitz, Christopher Thanos, Zhi Liu
Life of this patent
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Abstract
The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.
Claims13
A method for micronizing a hydrophobic agent, comprising:
- (i) dissolving the hydrophobic agent in an effective amount of a first solvent, with a polymer, wherein the hydrophobic agent and the first solvent form a mixture having a continuous phase,
- (ii) introducing a second solvent into the mixture, and
- (iii) introducing water into the mixture, wherein the water causes precipitation of the hydrophobic agent to produce a composition of micronized particles of hydrophobic agent having an average particle size of 1 micron or less, wherein the composition is free of surfactant.
Dependencies are inferred from the claim text.