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US 8,524,784 B2Granted
Polymer micelles containing anthracylines for the treatment of cancer
AssigneeIntezyne Technologies, Inc.
InventorsKevin N. Sill, Habib Skaff, Jonathan Rios-Doria
Life of this patent
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Abstract
The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using said micelles, and compositions thereof.
Claims11
An anthracycline loaded micelle comprising a multiblock copolymer, wherein said micelle has a drug-loaded inner core, a crosslinked outer core, and a hydrophilic shell, wherein the multiblock copolymer is of formula IX:
- wherein:
- each n is independently 10-2500;
- each s is independently 1 or 2
- each w is independently 0-30;
- each x is independently 1-30;
- each y is independently 5-50;
- each z is independently 5-50;
- M is Fe;
- and
- each R1 is independently —N3—OCH3 or
- wherein T is a targeting group moiety.
8 more elements
Dependencies are inferred from the claim text.