US 8,524,781 B2Granted

Organosulfur compounds, a method of making organosulfur compounds and their use for inhibiting the growth of tumour cells

AssigneeUniversity of Cape Town

InventorsCatherine Hart Kaschula, Roger Hunter, Mohamed Iqbal Parker

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Abstract

Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON—R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl; R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group; R6 is alkyl or substituted alkyl; and R7 and R8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumor cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.

Claims24

Dependent claims

A compound of formula (2)

wherein:
R1 is propyl, butyl, isopropyl, or isobutyl;
dansyl;
substituted linear or branched C1-C5 alkenyl;
or
substituted linear or branched C1-C5 alkyl;
in which the substituents are selected from
OR3;
NR4R5;
and
CONR7R8;
substituted or unsubstituted aromatic;
substituted or unsubstituted heteroaromatic,
in which
R3 is selected from H, COR9, para-methoxybenzyl, and trialkylsilyl, in which R9 is alkyl or substituted alkyl;
R4 and R5 are independently alkyl or R4 and R5 together form a phthalimido group;
R7 and R8 are independently alkyl or substituted alkyl;
and R2 is
linear or branched C1-C5 alkyl;
linear or branched C1-C5 alkenyl;
substituted linear or branched C1-C5 alkenyl;
or
substituted linear or branched C1-C5 alkyl;
in which the substituents are selected from
OR3;
NR4R5;
and
CONR7R8;
substituted or unsubstituted aromatic;
substituted or unsubstituted heteroaromatic;
in which
R3 is selected from H, COR9, para-methoxybenzyl, and trialkylsilyl, in which R9 is alkyl or substituted alkyl;
R4 and R5 are independently alkyl or R4 and R5 together form a phthalimido group;
R7 and R8 are independently alkyl or substituted alkyl,
wherein the compound of formula (2) excludes (E/Z)-4,5,9-trithiadodeca-1,6-diene-9-oxide.

32 more elements

Dependencies are inferred from the claim text.