US 8,524,774 B1Granted

Topical two step polytherapy for treatment of psoriasis and other skin disorders

AssigneeCymbiotics, Inc.

InventorsRaj R. Barathur, Jack Bain Bookout

Life of this patent

Estimating the term…

Loading patent…

Abstract

A process for treating psoriasis and similar skin disorders whereby two formulations are used. The first formulation in a cream, gel, lotion, foam or ointment base is used two or more times daily, and contains effective amounts of (but not limited to) methylcobalamin, niacinamide, select cetylated fatty esters, and antioxidants. This formulation is used to suppress immunoproliferative and inflammatory mediated activities that play significant roles in hyperproliferation and erythema. The second formulation, used selectively to reduce plaque thickening and to reduce irritation, contains effective amounts of (but not limited to) salicylic acid and select cetylated fatty esters in a cream, gel, lotion or ointment base, with pH optimized for exfoliation properties. The unique combination of salicylic acid (or other β- or α-hydroxy acid) and cetylated fatty esters provides keratolytic activity while suppressing irritation and inflammation. The invention for this novel two-step polytherapy, are disclosed including the mode of sequential administration.

Claims8

Dependent claims

A method for the treatment of psoriasis by use of a topical step-wise polytherapy, to a person in need thereof, comprising steps 1 and 2:

Step 1) Topically applying daily to a symptomatic portion of the skin a first composition comprising:
a) 4 to 40% of 4 or more cetylated fatty esters selected from the group consisting of cetyl arginine, cetyl 11-cyclohexylundecanoate, cetyl decanoate, cetyl dihomo-y-linolenate, cetyl docosapentanoate, cetyl eicosapentanoate, cetyl isolaurate, cetyl laurate, cetyl linolenate, cetyl 13-methyl myristate, cetyl myristoleate, cetyl myristate, cetyl oleate, cetyl ornithine, cetyl palmitate, cetyl palmitoleate, cetyl stearate, cetyl stearidonate and those having saturated or unsaturated hydrocarbon chains having 10 or more carbon atoms;
b) 5 to 30% of one or more polar solvents selected from the group consisting of propylene glycol, glycerol, ethylene glycol, 1,2,6-hexane triol, 1,2,4-butane triol, propylene glycol ether of methyl glucose or sorbitol, PEG 40 hydrogenated castor oil, dimethicone copolyol and polyethylene glycol;
and
c) a pharmaceutically acceptable vehicle;
and
Step 2) Topically applying a second composition, 2-3 times a week to the same portion of skin as the first composition, wherein the second composition comprises:
a) 4 to 40% of 4 or more cetylated fatty esters selected from the group consisting of cetyl arginine, cetyl 11-cyclohexylundecanoate, cetyl decanoate, cetyl dihomo-y-linolenate, cetyl docosapentanoate, cetyl eicosapentanoate, cetyl isolaurate, cetyl laurate, cetyl linolenate, cetyl 13-methyl myristate, cetyl myristoleate, cetyl myristate, cetyl oleate, cetyl ornithine, cetyl palmitate, cetyl palmitoleate, cetyl stearate, cetyl stearidonate and those having saturated or unsaturated hydrocarbon chains having 10 or more carbon atoms;
b) 1 to 20% of a keratolytic agent;
and
c) a pharmaceutically acceptable vehicle.

8 more elements

A method for the treatment of skin disorders relating to skin dermatitis, eruptions or lesions, by use of a topical step-wise polytherapy, to a person in need thereof, the method comprising steps 1 and 2:

Step 1) Topically applying daily to a symptomatic portion of the skin and surrounding asymptomatic portions of the skin a first composition comprising:
a) 4 to 40% of 4 or more cetylated fatty esters selected from the group consisting of cetyl arginine, cetyl 11-cyclohexylundecanoate, cetyl decanoate, cetyl dihomo-y-linolenate, cetyl docosapentanoate, cetyl eicosapentanoate, cetyl isolaurate, cetyl laurate, cetyl linolenate, cetyl 13-methyl myristate, cetyl myristoleate, cetyl myristate, cetyl oleate, cetyl ornithine, cetyl palmitate, cetyl palmitoleate, cetyl stearate, cetyl stearidonate and those having saturated or unsaturated hydrocarbon chains having 10 or more carbon atoms;
b) 5 to 30% of one or more polar solvents selected from the group consisting of propylene glycol, glycerol, ethylene glycol, 1,2,6-hexane triol, 1,2,4-butane triol, propylene glycol ether of methyl glucose or sorbitol, PEG 40 hydrogenated castor oil, dimethicone copolyol and polyethylene glycol;
and
c) a pharmaceutically acceptable vehicle;
Step 2) Topically applying a second composition, 2-3 times a week, only to the symptomatic portions of skin, wherein the second composition comprises:
a) 4 to 40% of 4 or more cetylated fatty esters selected from the group consisting of cetyl arginine, cetyl 11-cyclohexylundecanoate, cetyl decanoate, cetyl dihomo-y-linolenate, cetyl docosapentanoate, cetyl eicosapentanoate, cetyl isolaurate, cetyl laurate, cetyl linolenate, cetyl 13-methyl myristate, cetyl myristoleate, cetyl myristate, cetyl oleate, cetyl ornithine, cetyl palmitate, cetyl palmitoleate, cetyl stearate, cetyl stearidonate and those having saturated or unsaturated hydrocarbon chains having 10 or more carbon atoms;
b) 1 to 20% of a keratolytic agent;
and
c) a pharmaceutically acceptable vehicle;
wherein the skin disorder is selected from the group consisting of psoriasis, atopic dermatitis, seborrheic dermatitis, nummular eczema, ichthyosis vulgaris, keratosis pilaris, pemphigus and bullate pemphigoid.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/596,072Filed 28 Aug 2012
Granted: 3 Sep 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/06
Medicinal preparations characterised by special physical form: ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
A61K 31/23
Of acyclic acids, e.g. pravastatin: of acids having a carboxyl group bound to a chain of seven or more carbon atoms