Antioxidants for preventing and treating diseases caused by oxidative stress
OwnerIsaak Grigorievich Gitlininventor
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Abstract
Antioxidant compositions for the treatment and prophylaxis of illnesses associated with oxidative stress and lack of oxygen in the human body, comprising a complex of a metal selected from the group consisting of iron, copper, zinc and manganese with rutin and ascorbic acid and/or dihydroascorbic acid. Methods for synthesizing the antioxidant compositions and granulates, tablets and capsules containing antioxidant compositions are also provided.
Claims19
An antioxidant composition for the treatment or prophylaxis of an illness associated with oxidative stress, the composition comprising:
- a chemical reaction product comprising a complex comprising a metal, rutin and at least one of ascorbic acid and dehydroascorbic acid, the complex represented by the general formula (I):
- MemRu(AA)r(DGAA)p-Xn (I), wherein
- Me is a cation of a metal selected from the group consisting of iron, copper, zinc and manganese;
- Ru is rutin;
- AA is ascorbic acid;
- DGAA is dehydroascorbic acid;
- X is selected from the group consisting of SO4−2, CH3C(O)O− and −OOC—CH2—C(OH)(COO−)—CH2—COO−,
- m is a value from 1.0 to 3;
- n is a value from 0.7 to 9;
- and
- p/(r+p) is a value from 0 to 1, and each of p and r is a value of 0 to 0.5, provided that when p=0 then r is not equal to 0, and when r=0 then p is not equal to 0.
A method of making an antioxidant composition comprising a complex comprising a metal, rutin and at least one of ascorbic acid and dehydroascorbic acid, the complex represented by the general formula (I):
- MemRu(AA)r(DGAA)p-Xn (I), wherein
- Me is a cation of a metal selected from the group consisting of iron, copper, zinc and manganese;
- Ru is rutin;
- AA is ascorbic acid;
- DGAA is dehydroascorbic acid;
- X is selected from the group consisting of SO4−2, CH3C(O)O− and −OOC—CH2—C(OH)(COO−)—CH2—COO−,
- m is a value from 1.0 to 3;
- n is a value from 0.7 to 9;
- and
- p/(r+p) is a value from 0 to 1 and each of p and r is a value of 0 to 0.5, provided that when p =0 then r is not equal to 0, and when r =0 then p is not equal to 0, the method comprising:
- reacting ascorbic acid with a salt of a metal selected from the group consisting of iron, copper, zinc and manganese in solution to form a product;
- and,
- contacting the product with rutin at temperatures between room temperature and the boiling point of the solution to produce a rutin-containing product.
Dependencies are inferred from the claim text.