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US 8,524,766 B2Granted
Modulators of dopamine neurotransmission
AssigneeNsab, Filial Af Neurosearch Sweden AB, Sverige
InventorsClas Sonesson, Peder Svensson, Jonas Karlsson
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Abstract
The present invention relates to novel 1-(2,3-dihydro-1,4-benzodioxin-2-yl)-methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically as dopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Claims9
A compound of Formula 1:
- any of its stereoisomers or any mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof;
- wherein:
- X is O;
- R1 is selected from the group consisting of SOR8, SO2R8, SO2NH2 and SO2NH(CH3);
- R2 is selected from the group consisting of H, CN, F, Cl, Br, I and CH3;
- R3 is selected from the group consisting of C1-C5 alkyl, allyl, CH2CH2OCH3, CH2CH2CH2F, CH2CH2CHF2, CH2CH2F, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, CH2CH2OH, CH2CH2CH2OH, CH2CH(OH)CH3, CH2CH2COCH3, C3-C6 cycloalkyl,
- and
- R4 is selected from the group consisting of H, C1-C5 alkyl, allyl, CH2CH2OCH3, CH2CH2CH2F, CH2CH2CHF2, CH2CH2F, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, CH2CH2OH, CH2CH2CH2OH, CH2CH(OH)CH3, CH2CH2COCH3,
- R5, R6 and R7 are selected from the group consisting of H and CH3;
- and
- R8 is selected from the group consisting of C1-C3 alkyl, CF3, CHF2, CH2F and CN.
8 more elements
Dependencies are inferred from the claim text.