Thioxanthone-based autophagy inhibitor therapies to treat cancer

A method of treating a cancer, wherein the cancer is a lung cancer, a brain cancer, a central nervous system cancer, a breast cancer, a colon cancer, a leukemia, a myeloma, a prostate, or an ovarian cancer, the method comprising:

• a) administering an effective amount of a thioxanthone-based autophagy inhibitor selected from 1- ((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one, 1-(2-diethylaminoethylamino)-4-(hydroxymethyl)-9-thioxanthenone, N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thiaxanthen-4-yl]methyl]meth-anesulfonamide, indazole analogues thereof, or salts thereof, to a mammal in need thereof;
• and
• b) administering an effective amount of a cancer therapeutic autophagy inducing compound to a mammal in need thereof;
• wherein the administration of both the thioxanthone-based autophagy inhibitor and the cancer therapeutic autophagy inducing compound reduces a symptom associated with the cancer, thereby treating the cancer.