Thiazolidin-4-one derivatives

A method for the treatment of psoriasis comprising administering to a patient in need thereof an effective amount of a pharmaceutical composition containing at least one thiazolidin-4-one derivative of the General Formula (II)

• wherein:
• R14 represents lower alkyl;
• lower alkenyl;
• cycloalkyl;
• 5,6,7,8-tetrahydronaphth-1-yl;
• 5,6,7,8-tetrahydronaphth-2-yl;
• a phenyl group;
• or a phenyl group mono-, di- or tri-substituted independently with lower alkyl, halogen, lower alkoxy, or —CF3;
• R15 represents lower alkyl;
• allyl;
• cyclopropyl;
• cyclobutyl;
• cyclopentyl;
• or mono- or di-lower alkylamino;
• R16 represents hydrogen;
• hydroxy;
• lower alkoxy;
• lower alkyl;
• or halogen;
• R17 represents hydrogen, lower alkyl, or hydroxymethyl;
• R18, R19, R21 and R22 each represents independently hydrogen or methyl;
• R20 represents hydrogen or lower alkyl;
• and in case m represents the integer 1, R20 in addition represents lower alkoxy, hydroxy, —NH2, —NHR5 or —NR5R6, wherein R5 and R6 each represents independently lower alkyl;
• R23 represents hydrogen;
• lower alkyl;
• hydroxycarbonyl-lower alkyl;
• 1-glyceryl;
• or 2-glyceryl;
• m represents the integer 0 or 1,
• in free or pharmaceutically acceptable salt form.